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Draft NHMRC Information Paper: Effects of water fluoridation on dental and other health outcomes submission

ID: 
13
This submission reflects the views of
Individual Background: 
Scientist
Personal Details
First Name: 
Dr Geoff
Last Name: 
Pain
Specific Questions
Q1. A) Is the draft Information Paper presented in a manner that is easy to understand? : 
Disagree
Q1. B) Please provide details regarding your response to Question 1A: 
Other

The draft information paper fails to justify the exclusion of peer-reviewed evidence of harms known to be caused by the bio-accumulative, endocrine disrupting, neurotoxic carcinogen. The failure to receive submissions on the reviews which are largely long lists of the excluded scientific papers is a deliberate attempt to bury your heads in sand.

In answer to this question, I supply additional references that must be studied as part of this review, using the Section headings that you have chosen not to include in Questions 4-6.

Ethical considerations

Fluoridation is rejected by 95% of humanity as it breaches the fundamental medical requirements of 1] Do no harm 2] informed consent

See the work of a true expert in ethics, by Prof. Rita Barnett-Rose https://works.bepress.com/rita_barnett/3/

Water Fluoridation and any other health effects – Heart disease and high blood pressure

 I have reviewed the extensive science showing that Fluoride causes Heart disease, Stroke and Sudden Death by Ruptured Aorta see https://www.researchgate.net/publication/293593658_Fluoride_causes_Heart_Disease_Stroke_and_Sudden_Death

Conclusion
This brief survey shows that hundreds of scientists have studied the toxic impact of Fluoride onthe
cardiovascular system for over 70 years and the detailed evidence of harm is overwhelming. The
general public needs to be warned to minimize their total Fluoride intake. Especially vulnerable
groups such as the unborn, diabetics and those with compromised kidneys or thyroid must be
protected. Promotion of Fluoride and Fluoridation must cease. Politicians must purge the
bureaucracy of Fluoride promoters. Not a single excess death caused by water fluoridation can be
tolerated.
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Stary H C. 2000. Natural history of calcium deposits in atherosclerosis progression and regression. Z
Kardiol 89 Suppl 2:28–35.
Stookey G K, Muhler J C. 1963. Relationship between fluoride deposition and metastatic calcification
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Other

Endocrine disruption by Fluoride is well known and reported by the World Health Organization

I have summarized some key literature

https://www.researchgate.net/publication/285771633_Fluoride_is_a_bio-accumulative_endocrine_disrupting_neurotoxic_carcinogen_-_not_a_nutrient

References
Akiniwa, K. 1997. Re-examination of the acute toxicity of Fluoride. Fluoride 30(2) 89-104
Australian Government. 2015. Department of Health. Methodological framework for the review of
Nutrient Reference Values.
Belgium 2002. Belgian Council for Hygiene scientific opinion.
Bergman, Åke, Heindel, Jerrold J, Jobling, Susan, Kidd, Karen A and Zoeller, R Thomas. Editors 2013
State of the Science of Endocrine Disrupting Chemicals – 2012 An assessment of the state of the
science of endocrine disruptors prepared by a group of experts for the United Nations Environment
Programme and World Health Organization.
Choi, A.L., Zhang Y., Sun, G., Bellinger, D.C., Wang, K., Yang, X.J., Li, J.S., Zheng, Fug, Q.Y., Grandjean,
P. 2015. Association of lifetime exposure to fluoride and cognitive functions in Chinese children: A
pilot study. Neurotoxicology and Teratology. Volume47, 96–101.
Connett, E and Connett, P. 2002. Submission to the ATSDR.
Connett, P., Beck, J., Micklem, H.S., The Case Against Fluoride, How Toxic Waste Ended up in our
Drinking Water and the Bad Science and Politics thatKeep it There, Chelsea Green Publishing, White
River Junction, VT, USA, 2010.
Connett P. et al. 2015. Fluoride Action Network database. www.fluoridealert.org.
Deal, J.R. 2015. National Sanitation Foundation Sham FDA – Fraudulent Certifier of Fluoridation
Materials. Available from Research Gate.
Diesendorf, M. 1990. The health hazards of fluoridation: a re-examination, International Clinical
Nutrition Review 10(2) 304-321
Diesendorf M. 2006. Skeptic, Winter edition. Fluoridation: Unsafe, Ineffective and Unethical pp. 61-
63, 68.
EFSA Panel on Dietetic Products, Nutrition andAllergies 2013: Carlo Agostoni, Roberto Berni Canani,
Susan Fairweather-Tait, Marina Heinonen, HannuKorhonen, Sébastien La Vieille, Rosangela
Marchelli, Ambroise Martin, Androniki Naska, Monika Neuhäuser-Berthold, Grażyna Nowicka,
Yolanda Sanz, Alfonso Siani, Anders Sjödin, MartinStern, Sean (J.J.) Strain, Inge Tetens, Daniel Tomé,
Dominique Turck and Hans Verhagen. Scientific opinion on Dietary Reference Values for Fluoride.
EFSA Journal 11(8) 3332
FSANZ. Food Standards Australia and New Zealand. 2012. The 23rd Australian Total Diet Study.
International Association of Oral Medicine and Toxicology. 2003. Policy position on ingested fluoride
and fluoridation.
Kennedy D. 2015. personal communication
Ko, L. and K. Thiessen. 2015. A critique of recent economic evaluations of community water
fluoridation. International Journal of Occupational and Environmental Health 21, 91-120
Li, S., Smith, K.D., Davis, J.H., Gordon, P.B., Breaker, R.R. and S.A. Strobel. 2013. Eukaryotic resistance
to fluoride toxicity mediated by a widespread family of fluoride export proteins. Proceedings of the
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Lovering, E.M. 1963. Consumer Inquiries Section, USFDA to N.M. Wellesley, Mass. 8/15/63
MacArthur, J.D. 2015. Fluoride, Premature Birth and Impaired Neurodevelopment
Malin, A. and C.Till. 2015. Exposure to fluoridated water and attention deficit hyperactivity disorder
prevalence. Environmental Health 14, 17
Marshall T.A. et al. 2004. Associations between Intakes of Fluoride from Beverages duringInfancy
and Dental Fluorosis of Primary Teeth. Journal of the American College of Nutrition 23, 108-16
Maurer and Day. 1957. The Non-Essentiality of Fluoride in Nutrition. Journal of Nutrition, 62, 561-
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Needham, B. 2010. “Killer Smile” Report to Minister for Health and Human Services. Water
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National Research Council. 1993. Health Effects ofIngested Fluoride. National Academy Press,
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NHMRC 2007 Part B. Excluded Studies. 355 pages.
Pain, G. October 2015a. Fluoride doped Hydroxyapatite in Soft Tissues and Cancer – A Literature
Review. Available from Research Gate.
Pain, G. 2015b. Fluoride Causes Diabetes. Availablefrom Research Gate.
Pain, G. 2015c. NHMRC = Politics, Not Science. Australians Victims of Dangerous Fluoridation
Experiments. Available from Research Gate.
Pain, G. 2015d. Plumbosolvency exacerbated by Water Fluoridation. Available from Research Gate.
Peckham, S. Lowery, D. and S Spencer. 2015. Are fluoride levels in drinking water associated with
hypothyroidism prevalence in England? A largeobservational study of GP practice data and fluoride
levels in drinking water. J Epidemiol Community Health. pp 1-6.
Queensland Government Workplace Health and Safety. 2015. Fluoride health monitoring guidelines.
Sauerheber, R. 2013. Physiologic Conditions Affect Toxicity of Ingested Industrial Fluoride. Journal of
Environmental and Public Health Volume 2013
Saul, A.W. 2012. Dispensing with Fluoride. Orthomolecular Medicine News Service 7 May Editorial.
SCHER 2011. The Scientific Committee on Health and Environmental Risks. Critical review of any new
evidence on the hazard profile, health effects, and human exposure to fluoride and the fluoridating
agents of drinking water.
Stanton, R. 2015. personal communication.
Stockbridge, R.B., Kolmakova-Partensky, L., Shane,T., Koide, A., Koide, S., Miller, C. and S. Newstead.
2015. Crystal structures of a double-barrelled fluoride ion channel. Nature, 525, 548-551
Sutton, M., Kiersey, R., Farragher, L. and Long, J.2015. Health effects of water fluoridation.
U.S. Food and Drug Administration. 2006. Health Claim Notification for Fluoridated Water and
Reduced Risk of Dental Caries. Center for Food Safety and Applied Nutrition. Office of Nutritional
Products, Labeling, and Dietary Supplements,October 14, 2006
USPHS. 1966. Department of Health, Education andWelfare. Letter signed by Robert W Bonds.
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J.J., Jacobs, D. R., Lee, D. H., Shioda, T., Soto, A.
M., vom Saal, F. S., Welshons, W. V., Zoeller, R. T.,Myers, J. P. 2012. Hormones and endocrine-
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Wilson, G. H. III et al. 2014. An Approach to Breast Cancer Diagnosis via PET Imaging of
Microcalcifications Using 18F-NaF. The Journal of Nuclear Medicine (7) 1138-1143
World Health Organization 2014. Regional Assessment Report. Chemicals of Public Health Concern
and their management in the African Region.
Xiang Q, et al. 2003. Effect of fluoride in drinking water on children’s intelligence. Fluoride 36: 84-94.
Yazahmeidi, B and D’Arcy J. Holman, C. 2007. A surveyof suppression of public health information by
Australian governments. Aust N Z J Public Health. 31 (5) 51-7

 

Other

Plumbosolvency

It is well known that Fluoridation chemicals increase the dissolution of Lead from pipes, including PVC, solder and brass fittings used in the water supply distribution network and household. It is alos known that ceasing Fluoridation will reduce the concentration of Lead in drinking water giving health benefits that far outway imagined reduction of tooth decay.

 

I have reviewed the subject here: https://www.researchgate.net/publication/282439972_Plumbosolvency_exacerbated_by_Water_Fluoridation

References

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Auckland Healthcare Services. 2008. What is Plumbosolvency and are there any Health Risks?
Bonomi A, et al. 2001. Selective deleading process and bath for plumbing components made of a copper alloy. US Patent 6,284,053; September 4, 2001.
Borodin, PM, Zao, NGK and NS Petrov. 1974. Stability of the hexafluorosilicate ion in aqueous solutions of fluorosilicic acid, from19F NMR dataJournal of Structural Chemistry 14(4) 564-568
Burt, J, Grantham, W, Levason, W, Light, M E and Reid, G. 2015. Hexafluorosilicate and tetrafluoroborate coordination to lead(II) di- and tri-imine complexes – Unusual fluoroanion coordination modes. Polyhedron, 85, 530-36
Burt, J, Grantham, W, Levason, W and Reid. 2015. Lead(II) nitrate and hexafluorosilicate complexes with neutral diphosphine coordination Dalton Transactions , 244, 11533
Clabby, C. 2005. Water tests to plumb extent of lead problem. Durham among cities where chemical could cause toxic taint in tap water. The News and Observer, Raleigh, NC, September 3 [online]. Available: http://www.newsobserver.com
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Conley, DC, Yearwood BC, Parkin S and Atwood DA. 2002. Ammonium hexafluorosilicate salts. Journal of Fluorine Chemistry 115, 155-160
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Dabeka, RW, and AD McKenzie. 1987. Lead, cadmium, and fluoride levels in market milk and infant formulas in Canada. J. Assoc. Off. Anal. Chem. 70(4):754-757.
Dabeka, RW, and AD McKenzie. 1995. Survey of lead, cadmium, fluoride, nickel, and cobalt in food composites and estimation on dietary intakes of these elements by Canadians in 1986-1988. J. AOAC Int. 78(4):897-909.
Dudi A, Schock M, Murray N, Edwards M. 2005. Lead leaching from inline brass devices: a critical evaluation of the existing standard. J Am Water Works Assoc 97(8):66–78.
Edwards M, McNeill LS. 2002. Effect of phosphate inhibitors on lead release from pipes. J Am Water Works Assoc;94(1):79–92

Edwards, M, Triantafyllidou, S, Best, D. 2009. Elevated blood lead in young children due to lead-containing drinking water. Environ. Sci. Technol. 43, 1618−1623.
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European Commission. 2010. Critical review of any new evidence on the hazard profile, health effects, and human exposure to fluoride and the fluoridating agents of drinking water.
Finney WF, Wilson E, Callender A, Morris MD, Beck LW, 2006, Reexamination of Hexafluorosilicate Hydrolysis by 19F NMR and pH Measurement, Environ. Sci. Technol., 40 (8), pp 2572–2577
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Gooch, BF. 2015. U.S. Public Health Service Recommendation for Fluoride Concentration in Drinking Water for the Prevention of Dental Caries. Public Health Reports / July–August 2015 / Volume 130, 1-14
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Jackson PJ and JC Ellis. 2003. Report DWI 6173 Demonstration of Optimisation of Plumbosolvency Treatment and Control Measures. Final Report to the Drinking Water Inspectorate
Kennedy, David C. D.D.S 2003 IAOMT Policy position on ingested fluoride and fluoridation
Langphear, B P, Hornung, R, Khoury, J, Yolton, K, Baghurst, P, Bellinger, D C, Canfield, R L, Dietrich, K N, Bornschein, R, Greene, T, Rothenberg, S J, Needleman, H L. Schnaas, L, Wasserman, G, Graziano, J, Roberts, R. 2005. Low-level environmental lead exposure and children’s intellectual function: An international pooled analysis. Environ. Health Perspect. 113, 894−899.
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Luo G, Niu R, Sun Z, Zhang J, Wang J, Wang C, Wang J. 2011. Reduction of CAMKII expression in the hippocampus of rats from ingestion of fluoride and/or lead. Fluoride April-June 44(2):63–69
Maas, RP, Patch, SC and AM Smith. 2005. Effects of Fluorides and Chloramines on Lead Leaching from Leaded-Brass Surfaces. Technical Report 05-142. Environmental Quality Institute, University of North Carolina, Asheville, NC. June
Maas, R P, Patch, S C, Christian, A and Coplan, M J. 2007 Effects of fluoridation and disinfection agent combinations on lead leaching from leaded-brass parts NeuroToxicology 28, 1023–1031
Macek, MD, Matte, TD Sinks, T and DM Malvitz. 2006. Blood lead concentrations in children and method of water fluoridation in the United States, 1988-1994. Environ. Health Perspect. 114(1):130-134.

Mahaffey, KR et al 1976. Effect of High Fluorine (F) intake on tissue lead (Pb) Concentrations. Fed. Proc., 35, 256.
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Xiang Q, et al. 2003a. Effect of fluoride in drinking water on children’s intelligence. Fluoride 36: 84-94.
Xiang Q, et al. 2003b. Blood lead of children in Wamiao-Xinhuai intelligence study. Fluoride 36: 198-199

 

 

Other

Diabetes is caused by Fluoride

I have reviewed the subject here: https://www.researchgate.net/publication/273442062_Fluoride_Causes_Diabetes

References

Note: Those marked * were deliberately excluded from the NMRC 2007 Review.
Alavi, A A, Amirhakimi, E and Karami, B. 2006 The prevalence of dental caries in 5-18-year-old insulin-dependent diabetics of Fars Province, southern Iran Archives of Iranian Medicine, 9( 3) 254-260 *
Australian Health Ministers’ Advisory Council (AHMAC) Steering Committee for National Planning for Oral Health 2001 Oral health of Australians: National planning for oral health improvement: Final report. South Australian Department of Human Services.
Avtsyn, A P and Zhavoronkov, A A. Fluorosis pathology (Novosibirsk, 1981) cited in Tokar 1992.
Banu Priya C A Y, Anitha K, Murali Mohan E, Pillai K S and Murthy P B. 1997. Toxicity of fluoride to diabetic rats. Fluoride 30(1) 43-50.
Basha M P, Saumya S M. 2013 Influence of fluoride on streptozotocin induced diabetic nephrotoxicity in mice: Protective role of Asian ginseng (Panax ginseng) & banaba (Lagerstroemia speciosa) on mitochondrial oxidative stress The Indian Journal of Medical Research February 137(2) 370–379
Bergman, Åke, Heindel, Jerrold J, Jobling, Susan, Kidd, Karen A and Zoeller, R Thomas. Editors 2013 State of the Science of Endocrine Disrupting Chemicals – 2012 An assessment of the state of the science of endocrine disruptors prepared by a group of experts for the United Nations Environment Programme and World Health Organization.
Birkner E, Grucka-Mamczar E, Zalejska-Fiolka J et al. 2006. Influence of sodium fluoride and caffeine on the concentration of fluoride ions, glucose, and urea in blood serum and activity of protein metabolism enzymes in rat liver. Biol Trace Elem Res. 112(2) 169-74.
Bolgul, B S, Celenk, S, Ayna, B E, Atakul, F and Uysal, E. 2004 Evaluation of caries risk factors and effects of a fluoride-releasing adhesive material in children with insulin-dependent diabetes mellitus (IDDM): Initial first-year results Acta Odontologica Scandinavica, 62(5) 289-292. *
Boros, I, Keszler, P, Csikós G and Kalász H. 1998 Fluoride intake, distribution, and bone content in diabetic rats consuming fluoridated drinking water. Fluoride 31(1) 33-42
Cettour-Rose, P, Theander-Carrillo, C , Asensio, C, Klein, M, Visser, T J, Burger, A G, Meier C A, and Rohner-Jeanrenaud F. 2005. Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion. Diabetologia 48(4) 624-633 cited in NRC 2006.
Chang, C H, Tsai, R K, Wu, W C, Kuo, S L, and Yu, H S. 1997 Use of dynamic capillaroscopy for studying cutaneous microcirculation in patients with diabetes mellitus. Microvascular Research 53 121-127 *
Chehoud, K A, Chiba, F Y, Sassaki, K T, Garbin, C A, Sumida, D H. 2008 Effects of fluoride intake on insulin sensitivity and insulin signal transduction Fluoride October-December 41(4) 270–275
Chiba F Y, Colombo N H, Shirakashi D J, Da Silva V C, Moimaz S A S, Garbin C A S, Antoniali C and Sumida D H. 2012 NaF treatment increases TNF-a and resistin concentrations and reduces insulin signal in rats. Journal of Fluorine Chemistry 136 3–7
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Water Fluoridation and any other health effects – Cancer

Fluoride causes cancer and one of the most serious mechanisms is very well understood - enhanced deposition of Fluoride doped Hydroxyapatite in the soft tissues that causes malignancy.

I have reviewed the subject here: https://www.researchgate.net/publication/272421380_Fluoride_doped_hydroxyapatite_in_soft_tissues_and_cancer_A_literature_review

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Supertoxic elements delivered deliberately to the population via Fluoridation chemicals.

It is scandalous that you fail to deal with major hazards present in the industrial Fluoride waste used to poison Australian water.

The elements which are not safe at any level are the Genotoxic Class I carcinogens:

Arsenic

Beryllium

Cadmium

Chromium

Nickel

Thorium and its decay products

Uranium and its decay products

The target for these elements is ZERO and yet you condone the deliberate addition of them to water and food prepared with that water contaminated by deliberate addition of industrial Fluoride waste!

Q2. A) Is it clear how NHMRC reviewed the health and dental effects of water fluoridation? : 
Disagree
Q2. B) Please provide details regarding you response to Question 2A: 

The NHMRC deliberately excluded consideration of essential science by making ridiculous exclusion criteria.

Q3. A) Is the Fluoride Reference Group’s interpretation of the evidence clearly described in the draft Information Paper?: 
Disagree
Q3. B) Please provide details regarding your response to Question 3A: 

The FRG's interpretation of the tiny amount of selected evidence is biased due to the composition of the panel.

Q5. Is there additional evidence on any other health effects of water fluoridation that should be considered in the draft Information Paper?: 

See all the references supplied in answer to Question 1. plus these highly relevant papers. 2016 letter to the National Governors Association from consumer advocate Erin Brockovich, water specialist Robert Bowcock, and “elite” whistleblower attorney Michael D. Kohn (lobbying & advocacy) http://fluoridealert.org/wp-content/uploads/brockovich-2016.pdf 2016 letter to the American Thyroid Association from Richard Shames, MD, et al. (endocrine disruption & cancer) http://www.ehcd.com/wp-content/uploads/2016/02/2016_02_11_ATALtrCWF.pdf 2015 letter to Institute of Medicine from Erin Brockovich, American Academy of Environmental Medicine, “super lawyer” David P. Matthews, et. al. (contraindications & safety): https://www.aaemonline.org/pdf/LetterIOM_2015.04.27.pdf 2015 IAOMT position paper opposing fluoridation (toxicity & carcinogenicity): https://iaomt.org/iaomt-position-fluoridation/ 2014 Canadian legal memo and scientific affidavit of 2006 NRC panelist, Dr. Kathleen Thiessen (disproportionate harm & susceptible populations): http://momsagainstfluoridation.org/sites/default/files/Fluoridation-Lega... 2016 Fluoride, Chloramine & Lead Resource Sheet (bad for people, pipes, and planet): http://momsagainstfluoridation.org/sites/default/files/pdf-documents/Flu... 2016 Comment on Oral Health Coalition thesis (intimidation & deception): https://drive.google.com/open?id=0BxPjobYjirCIMDdEaF90WE44VzQ Video showing the [NHMRC has removed third party information] acknowledgement, behind closed doors, of the harms of Fluoridation https://www.youtube.com/watch?v=SjSp3Bzgu4I&feature=youtu.be

Q6. Is there any other supporting material relevant to making decisions on water fluoridation in the Australian context that should be considered in the draft Information Paper?: 

Work by real scientists using high technology has debunked the theory that Fluoride has any value in mineralization or remineralization of tooth enamel. See for example the excellent work of Professor of Dentistry Mitsuo Kakei and his coworkers Aspects Regarding Fluoride Treatment for Reinforcement and Remineralization of Apatite Crystals Journal of Hard Tissue Biology 21[3] (2012) p257-266 These workers found that "fluorapatite crystals were not generated by daily intake of F ions in developing rat tooth enamel. A differential gas pressure method demonstrated that the harmfulness of F exposure during the nucleation process of calcified hard tissues was much greater than that of Cd exposure. These results demonstrate that F treatments have no effect on improving crystal quality or remineralization and are inconsistent with the purpose of public health." Similarly, real scientists using advanced technology have shown that exposure of tooth enamel to Fluoride produces, at most, only 6nm depth of fluoride attachment and this is likely an over-estimate because surface roughness and increasing crater diameter during ion ablation increases the apparent depth of penetration. See https://www.researchgate.net/publication/49621915_Elemental_Depth_Profil... Failure to consider excellent reviews of Fluoride Toxicology is negligent. See for example the excellent review by Barbier et al https://www.researchgate.net/publication/45281342_Molecular_mechanisms_o...

Page reviewed: 4 July, 2017