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Draft NHMRC Information Paper: Effects of water fluoridation on dental and other health outcomes submission

This submission reflects the views of
Individual Background: 
Personal Details
First Name: 
Dr Geoff
Last Name: 
Specific Questions
Q1. A) Is the draft Information Paper presented in a manner that is easy to understand? : 
Q1. B) Please provide details regarding your response to Question 1A: 

The draft information paper fails to justify the exclusion of peer-reviewed evidence of harms known to be caused by the bio-accumulative, endocrine disrupting, neurotoxic carcinogen. The failure to receive submissions on the reviews which are largely long lists of the excluded scientific papers is a deliberate attempt to bury your heads in sand.

In answer to this question, I supply additional references that must be studied as part of this review, using the Section headings that you have chosen not to include in Questions 4-6.

Ethical considerations

Fluoridation is rejected by 95% of humanity as it breaches the fundamental medical requirements of 1] Do no harm 2] informed consent

See the work of a true expert in ethics, by Prof. Rita Barnett-Rose https://works.bepress.com/rita_barnett/3/

Water Fluoridation and any other health effects – Heart disease and high blood pressure

 I have reviewed the extensive science showing that Fluoride causes Heart disease, Stroke and Sudden Death by Ruptured Aorta see https://www.researchgate.net/publication/293593658_Fluoride_causes_Heart_Disease_Stroke_and_Sudden_Death

This brief survey shows that hundreds of scientists have studied the toxic impact of Fluoride onthe
cardiovascular system for over 70 years and the detailed evidence of harm is overwhelming. The
general public needs to be warned to minimize their total Fluoride intake. Especially vulnerable
groups such as the unborn, diabetics and those with compromised kidneys or thyroid must be
protected. Promotion of Fluoride and Fluoridation must cease. Politicians must purge the
bureaucracy of Fluoride promoters. Not a single excess death caused by water fluoridation can be
Those marked with an asterisk were found but deliberately ignored by The Australian National
Health and Medical Research Council in 2007.
Adeagbo AS, Triggle CR. 1991. Mechanism of vascularsmooth muscle contraction by sodium fluoride
in the isolated aorta of rat and rabbit. J Pharmacol Exp Ther. Jul 258(1):66-73.
Afolabi OK, Oyewo EB, Adekunle AS, Adedosu OT, Adedeji AL. 2013. Oxidative indices correlatewith
dyslipidemia and pro-inflammatory cytokine levels in fluoride-exposed rats. Archives of Industrial
Hygiene and Toxicology 64(4):521-9
Agalakova NI and Gusev GP. 2012. Molecular Mechanisms of Cytotoxicity and Apoptosis Induced by
Inorganic Fluoride. International Scholarly Research Notices. Cell Biology. Available from
AIHW Australian Institute of Health and Welfare 2016. http://www.aihw.gov.au/deaths/leading-
Alexopoulos N, Raggi P. Calcification in atherosclerosis. Nat Rev Cardiol 2009; 6:681688
Allmann DW, Dunipace A, Jaouni S, Curro FA. 1986. Stimulation of cAMP accumulation in rat aorta
and diaphragm by fluorine containing compounds. Res Commun Chem Pathol Pharmacol 52(3):275-
Amini H, Taghavi Shahri S M T, Amini M, Mehrian M R, Mokhayeri Y and Yunesian M. 2011. Drinking
water fluoride and blood pressure: an environmental study. Biol Trace Elem Res 144:157-63.
Apostolakis S, Vogiatzi K, Amanatidou V and Spandidos DA. 2009. Interleukin 8 and cardiovascular
disease. Cardiovascular Research. 84(3) 353-360.
Arad Y, Spadaro LA, Goodman K, NewsteinD, Guerci AD. 2000. Prediction of coronary eventswith
electron beam computed tomography. J Am Coll Cardiol 36:125360.
Arangino S, Cagnacci A, Angiolucci M, Vacca AMB, Longu G, Volpe A and Melis GB. 1999. Effects of
melatonin an vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am JCardiol 83, 1417
Artru A A, Lam A M, Johnson J O, and Sperry R J. 1997. Intracranial pressure, middle cerebral artery
flow velocity, and plasma inorganic fluoride concentrations in neurosurgical patients receiving
sevoflurane or isoflurane. Anesthesia and Analgesia,85(3) 587-592. *
Basha MP, Sujitha NS. 2011. Chronic fluoride toxicityand myocardial damage: antioxidant offered
protection in second generation rats. Toxicol Int 18(2):99-104.
Barbier O, Arreola-Mendoza L, Del Razo L M.2010. Molecular mechanisms of fluoride toxicity.
Chemico-Biological Interactions 188:319-33.
Bera I, Sabatini R, Auteri P, Flace P, Sisto G, Montagnani M, Potenza MA, Marasciulo FL, Carratu MR,
Coluccia A, Borracci P, Tarullo A, Cagiano R. 2007. Neurofunctional effects of developmental sodium
fluoride exposure in rats. Eur Rev Med Pharmacol Sci 11:211-24.
Bharti VK, Srivastava RS, Kumar H, Bag S, MajumdarAC, Singh G, Pandi-Perumal SR, Brown GM.
2014. Effects of melatonin and epiphyseal proteins on fluoride-induced adverse changes in
antioxidant status of heart, liver, and kidney ofrats. Advances in Pharmacological Sciences.
Bito H, Atsumi K, Katoh T, and Ohmura M. 1999. Effects of sevoflurane anesthesia on plasma
inorganic fluoride concentrations during and after cardiac surgery. Journal of Anesthesia, 13(3)156-
160. *
Blank T. 2012. Fluoride and Myocardial Damage Fluoride Action Network.
Bogatcheva N V, Wang P, Birukova A A, Verin A D, and Garcia J G N. 2006. Mechanism of fluoride-
induced MAP kinase activation in pulmonary arteryendothelial cells. American Journal of Physiology
- Lung Cellular and Molecular Physiology. 290(6)L1139-L1145. *
Booth J V, Landolfo K P, Chesnut L C, Bennett-Guerrero E, Gerhardt M A, Atwell D M, El Moalem H E,
Smith M S, Funk B L, Kuhn C M, Kwatra MM, and Schwinn D A. 1998. Acute depression of myocardial
(beta)-adrenergic receptor signaling during cardiopulmonary bypass. Impairment of the adenylyl
cyclase moiety. Anesthesiology. 89(3) 602-611. *
Butanda-Ochoa A, Höjer G, Morales-Tlalpan V, Díaz-Muñoz M. 2006. Recognition and activation of
ryanodine receptors by purines. Curr Med Chem. 13(6):647-57
Cao J, Chen J, Wang J, Jia R, Xue W, Luo Y and GanX. 2013. Effects of fluoride on liver apoptosis and
Bcl-2, Bax protein expression in freshwater teleost, Cyprinus carpio. Chemosphere 91(8), 1203-1212.
CDC 2014. National Center for Chronic Disease Prevention and Health Promotion. National Diabetes
Statistics Report, 2014
Cheng R, Nie Q, Sun H, Zhang Y, Wu L, Ma Y, YanX. 2013. Fluoride-induced oxidative stress in rat
myocardium through the Bax/Bcl-2 signalling pathway. Fluoride. 46(4):198203.
Cicek E, Aydin G, Akdogan M, Okutan H. 2005. Effects of chronic ingestion of sodium fluorideon
myocardium in a second generation of rats. Human Exper Toxicol 24:79-87.
Coleman K, Harvey C and Weston A. Health Technology Analysts Pty Ltd. 2007a. A systematic review
of the efficacy and safety of fluoridation Part A: Review Methodology and Results
Coleman K, Harvey C and Weston A. Health Technology Analysts Pty Ltd. 2007b. Part B: Excluded
Conzen PF, Kharasch ED, Czerner SF, Artru AA, Reichle F, Michalowski P. 2002. Lowflow sevoflurane
compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.
Anesthesiology 97: 578-584.
CSBP. 2005. Fluorosilicic Acid Material SafetyData Sheet.
Cushing DJ, Sabouni MH, Brown GL and Mustafa F. 1990. Fluoride produces endothelium-dependent
relaxation and endothelium-independent contraction in coronary artery. J Pharmacol Exp Ther
Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, Davis V, Gutierrez-Ramos J-C, Connelly P W,
and Milstone D S. 2001. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin
Invest. 107(10) 1255-1262
Dede O, Varol E, Altinbas A, Varol S. 2011. Chronic fluoride exposure has a role in etiology of
coronary artery ectasia: sialic acid/glycosaminoglycan ratio. Biol Trace Elem Res 143:695-701.
Derlin T, Richter U, Bannas P, Begemann P, BuchertR, Mester J and and Klutmann S. 2010. Feasibility
of 18 F-sodium fluoride PET/CT for imaging of atherosclerotic plaque. J Nucl Med 51:862865
Derlin T, Toth Z, Papp L, Wisotzki C, Apostolova I, Habermann CR, Mester J and Klutmann S. 2011.
Correlation of inflammation assessed by 18 F-FDGPET, active mineral deposition assessed by 18F-
Fluoride PET, and vascular calcification in atherosclerotic plaque: a dual-tracer PET/CT study. J Nucl
Med 52:10201027.
Derlin T, Wisotzki C, Richter U, Apostolova I, Bannas P, Weber C, Mester J and Klutmann S. 2011. In
vivo imaging of mineral deposition in carotid plaque using 18 F-sodium fluoride PET/CT: correlation
with atherogenic risk factors. J Nucl Med 52:362368.
Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA,
O'Leary DH, Tracy R, Watson K, Wong ND, and Kronmal RA. 2008. Coronary calcium as a predictor of
coronary events in four racial or ethnic groups. N Engl J Med 358:13361345.
Doherty TM, Fitzpatrick LA, Inoue D, Qiao JH, FishbeinMC, Detrano RC, Shah PK, Rajavashisth TB.
2004. Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev 25:629
Dönmez N, Çinar A. 2003. Effects of chronic fluorosison electrocardiogram in sheep. Biol Trace Elem
Res 92:115-21.
Dunphy MP, Freiman A, Larson SM, Strauss HW.2005. Association of vascular 18 F-FDG uptake with
vascular calcification. J Nucl Med 46: 12781284
Durrant-Peatfield B. 2004. The Effects of Fluoride on the Thyroid Gland.
Dweck MR, Jenkins WS, Vesey AT, Pringle MA, ChinCW, Malley TS, Cowie WJ, Tsampasian V,
Richardson H, Fletcher A, Wallace WA, Pessotto R, van Beek EJ, Boon NA, Rudd JH, Newby DE. 2014.
18F-sodium fluoride uptake is a marker of active calcification and disease progression in patients
with aortic stenosis. Circ Cardiovasc Imaging. Mar 1;7(2):371-8
Elwood PC. Iron, magnesium and ischaemic heart disease. 1994. Proc Nutr Soc 53:599603.
FAN 2016 Fluoride Action Network regularly updates its searchable database with new information
on cardiovascular disease. http://fluoridealert.org/issues/health/cardio/
Fitzgerald PJ, Ports TA, Yock PG. 1992. Contribution of localized calcium deposits to dissection after
angioplasty. An observational study using intravascular ultrasound. Circulation 86:6470.
Flora SJ, Pachauri V, Mittal M, Kumar D. 2011. Interactive effect of arsenic and fluoride on cardio-
respiratory disorders in male rats: possible role of reactive oxygen species. Biometals. 24(4):615-28.
Folsom AR, Kronmal RA, Detrano RC, O’Leary DH, Bild DE, Bluemke DA, Matthew J. Budoff MJ, Liu K,
Shea S, Szklo M, Tracy RP, Watson KE, Burke GL. 2008. Coronary artery calcification compared with
carotid intima-media thickness in the predictionof cardiovascular disease incidence: the Multi-
Ethnic Study of Atherosclerosis (MESA). Arch Intern Med 168:13331339.
Girotti L, Lago M, Ianovsky O, Elizari MV,Dini A, Lloret SP, Albornoz LE and Cardinali DP. 2003. Low
urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure. Endocrine 22,
Gutowska I, Baranowska-Bosiacha I, Baskiewicz M,Milo B, Siennicka A, Marchiewicz M, Wiszniewska
B, Machalinski B, Stachowska E. 2010. Fluoride asa pro-inflammatory factor and inhibitor of ATP
bioavailability in differentiated human THP1 monocytic cells. Toxicology Letters 196: 74-79
Hanhijärvi H and Penttila I. 1981. Ionic plasma fluoride concentrations related to some diseases in
patients from a fluoridated community. Proc Finn Dent Soc. 77(6):324-9.
Hanhijärvi H, Penttilä I. 1981. The relationship between human ionic plasma fluoride and serum
creatinine concentrations in cases of renal and cardiac insufficiency in a fluoridated community. Proc
Finn Dent Soc 77(6):330335.
Yuichi Hattori, Naoyuki Matsuda, Atsushi Sato, Satoko Watanuki, Hiroshi Tomioka, Hisao Kawasaki,
and Morio Kanno. 2000. Predominant Contribution of the G Protein-Mediated Mechanism to NaF-
Induced Vascular Contractions in Diabetic Rats: Association with an Increased Level of Gqa
Expression. The Journal Of Pharmacology And Experimental Therapeutics. 292(2) 761-768.
Haufroid V, Cardinal S, Licot C, Villalpando M L, VanObbergh L, Clippe A, and Lison D. 2000.
Biological monitoring of exposure to sevoflurane in operating room personnel by the measurement
of hexafluoroisopropanol and fluoride in urine. Biomarkers 5(2) 141-151. *
Houtman J P. 1996. Trace elements and cardiovasculardiseases. Journal of Cardiovascular Risk 3(1)
18-25. *
HRI Heart Research Institute 2016. http://www.hri.org.au/about-heart-disease/facts-about-heart-
Hussein MR, Ahmed OG, Hassan AF, Ahmed MA.2007. Intake of melatonin is associated with
amelioration of physiological changes, both metabolic and morphological pathologies associated
with obesity: an animal model. Int J Exp Pathol. 88:19-29
Ibrahim AA, Mohammad A, El-Khalek A. 2013. Possible protective role of calcium against fluoride
induced cardio toxicities in adult male albino rats. Journal of American Sciences. 9(4):499-510.
Jehle A B, Li Y, Stechschulte A C, Stechschulte D J, and Dileepan K N. 2000. Endotoxin and mast cell
granule proteases synergistically activate human coronary artery endothelial cells to generate
interleukin-6 and interleukin-8. Journal of Interferon and Cytokine Research 20(4) 361-368. *
Jethanandani P, Sharma K and Susheela AK. 1995. Circulating haptoglobin of rabbits after acute and
chronic fluoride toxicity. Med Sci Res 23, 301-303
Ji F, et al. 2004. Study on the cardiovascular damage of skeletal fluorosis patients. Chin J Ctrl Endem
Dis 19(6):321-3 (Abstract).
Johnson J L, Jackson C L, Angelini G D, and George S J. 1998. Activation of matrix-degrading
metalloproteinases by mast cell proteasesin atherosclerotic plaques. Arteriosclerosis, Thrombosis,
and Vascular Biology 18(11) 1707-1715. *
Johnson RC, Chapman S M, Dong Z M, Ordovas J M, Mayadas T N, Herz J, HynesR O, Schaefer E J,
and Wagner D D. 1997. Absence of P-selectin delays fatty streak formation in mice. J Clin Invest.
Johnson RC, Leopold JA, Loscalzo J. 2006. Vascular calcification: pathobiological mechanisms and
clinical implications. Circ Res 99:10441059
Kaipio J, Nayha S and Valtonen V. 2004, Fluoride in the drinking water and the geographical variation
of coronary heart disease in Finland, European Journal of Cardiovascular Prevention and
Rehabilitation 11(1) 56-62.
Kant V, Srivastava AK, Verma PK, Raina R, Pankaj NK. 2010. Alterations in electrocardiographic
parameters after subacute exposure of fluoride and ameliorative action of aluminum sulphate in
goats. Biological Trace Element Research 134:188-94.
Karademir S, Akcam M, Kuybulu AE, Olgar S, Oktem F. 2011. Effects of fluorosis on QT dispersion,
heart rate variability and echocardiographic parameters in children. Anadolu Kardiyol Derg
(Anatolian Journal of Cardiology ) 11:150-5.
Kearney R. 2015. Melatonin in Health and Disease Effects of Fluoride. Presented at Sydney
Conference: Water Fluoridation Exploring the Science. University of Technology 21 Feb 2015
Kilicalp D, Cinar A, Belge F. 2004. Effects of chronic fluorosis on electrocardiogram in dogs. Fluoride
Kumar N, Sood S, Singh M, Makkar B, Sharma S. 2010. Effects of sodium fluoride on the
electrocardiogram of male rabbits. Fluoride 43(2):124-7.
Kousa A, Moltchanova E, Viik-Kajander M, Rytkonen M, Tuomilehto J, Tarvainen T, and Karvonen M.
2004. Geochemistry of ground water and the incidence of acute myocardial infarction in Finland.
Journal of Epidemiology and Community Health 58(2) 136-139.*
Kusano KF, Nakamura K, Kusano H, Nishii N, Banba K, Ikeda T, Hashimoto K, Yamamoto M, Fujio H,
Miura A, Ohta K, Morita H, Saito H, Emori T, Nakamura Y, Kusano I, Ohe T. 2004. Significance of the
level of monocyte chemoattractant protein-1 in human atherosclerosis. Circ J Jul 68(7):671-6.
Lakoski SG, Greenland P,Wong ND, Schreiner PJ, Herrington DM, Kronmal RA, Liu K, Blumenthal RS.
2007. Coronary artery calcium scores and risk for cardiovascular events in women classified as ‘low
risk’ based on Framingham risk score: the multi-ethnic study of atherosclerosis (MESA). Arch Intern
Med 167: 24372442.
Leone NC, Geever EF, Moran NC. 1956. Acute and subacute toxicity studies of sodium fluoride in
animals. Pub Health Rep 71(5):459-67.
Ley K and Huo Y. 2001. VCAM-1 is critical in atherosclerosis. J Clin Invest. May 15; 107(10): 1209
Liao W, Guan ZZ, Liu YF, Xu SQ, Wu CX, Li Y, Xiao Y, Deng J, Ouyang K, Zhou CZ, Xie M, Yu YN, Shan
KR. 2013. Observations on electrocardiograms in a population living in a region with coal-burning-
borne endemic fluorosis after comprehensive controls. Chinese Journal of Endemiology. 32(4):424-
Liu H, Gao Y, Sun L, Li M, Li B, Sun D. 2014. Assessment of relationship on excess fluoride intake from
drinking water and carotid atherosclerosis development in adults in fluoride endemic areas, China.
International Journal of Hygiene and Environmental Health. 217(2-3):413-20
Li R, Lynch C, Burns T, Hanson J, Munger R, Isacson P. 1992. Fluoride in drinking water and
intracardiac blood flow defects in Iowa. Am J Epidemiology, SER Abstracts, 15 Oct 1992: 1030.
Li Y, Berenji G R, Shaba W F, Taftia B, Yevdayev E and Dadparvar S.2011. Association of vascular
fluoride uptake with vascular calcification and coronary artery disease Nucl Med Commun 33:1420
Lu J, Xu Q, Zheng J, Liu H, Li J, Chen K. 2009. Comparative proteomics analysis of cardiac muscle
samples from pufferfish Takifugu rubripes exposedto excessive fluoride: initial molecular response
to fluorosis. Toxicology Mechanisms and Methods. 19(6-7):468-75.
Ma Y, Niu R, Sun Z, Wang J, Luo G, Zhang J, WangJ. 2012. Inflammatory responses induced by
fluoride and arsenic at toxic concentration in rabbit aorta. Arch Toxicol 86:849-56.
MacArthur JD. 2015. Fluoride, Premature Birth and Impaired Neurodevelopment. Available from
Maheswaran R, Morris S, Falconer S, Grossinho A, Perry I, Wakefield J and Elliott, P. 1999.
Magnesium in drinking water supplies andmortality from acute myocardial infarction in north west
England, Heart 82(4) 455-460. *
Martin-Pardillos A, Sosa C, Millán Á, Sorribas V. 2014. Effect of water fluoridation on thedevelopment of medial vascular calcification in uremic rats. Toxicology 318: p. 40-50
McCollough CH, Ulzheimer S, Halliburton SS, Shanneik K, White RD, Kalender WA. 2007. Coronary
artery calcium: a multi-institutional, multimanufacturer international standard for quantificationat
cardiac CT. Radiology 243:527538.
McCully KS, Chemical pathology of homocysteine. IV. 2009. Excitotoxicity, oxidative stress,
endothelial dysfunction, and inflammation. Ann Clin Lab Sci. Summer 39(3):219-32
McGrath B J, Hodgins L R, DeBree A, Frink E J,Nossaman B D, and Bikhazi G B. 1998. A multicenter
study evaluating the effects of sevoflurane on renal function in patients with renal insufficiency.
Journal of Cardiovascular Pharmacology and Therapeutics 3(3) 229-234.*
Mehdi S, Jarvi ET, Koehl JR, McCarthy JR, BeyP. 1990. The mechanism of inhibition of S-adenosyl-L-
homocysteine hydrolase by fluorine-containing adenosine analogs. J Enzyme Inhib. 1990;4(1):1-13.
Menke A, Muntner P, Batuman V, SilbergeldEK, Guallar E. 2006. Blood lead below 0.48 μmol
(10μg/dL and mortality among US adults. Circulation 114:1388-94
Miller AH. 1952. Fluoridation of water. Congressional Record United States Congress Report.
Morgan M P, Cooke M M and McCarthy G M.2005. Microcalcifications associated with breast
cancer: an epiphenomenon or biologically significant feature of selected tumors? Journal of
Mammary Gland Biology and Neoplasia April 10(2)181-187.
Morris VB, Keelan T, Leen E, Keating J, Magee H,O’Neill JO, Galvin J. 2009. Sudden cardiac death in
the young: a 1 year post mortem analysis in theRepublic of Ireland. Ir J Med Sci 178(3): 257-261
Mullerwieland D, Behnke B, Koopmann K, KroneW. 1994. Melatonin Inhibits LDL Receptor Activity
and Cholesterol-Synthesis in Freshly Isolated Human Mononuclear Leukocytes. Biochem Biophys Res
Commun 203:416-21
Namiki M, Kawashima S, Yamashita T, Ozaki M, Hirase T, Ishida T, Inoue N, Hirata K, Matsukawa A,
Morishita R, Kaneda Y, Yokoyama M. 2002. Local overexpression of monocyte chemoattractant
protein-1 at vessel wall induces infiltrationof macrophages and formation of atherosclerotic lesion:
synergism with hypercholesterolemia. Arterioscler Thromb Vasc Biol. 22:115120.
Navas-Acien A, Guallar E, Silbergeld E, Rothenberg SJ. 2007. Lead exposure and cardiovascular
disease a systematic review. Environ Health Perspect 115:472-82
Ng, C K, Soufer, R and McNulty, P H. 1998 Effect of hyperinsulinemia on myocardial fluorine-18-FDG
uptake Journal of Nuclear Medicine, 39(3) 379-383 *
O’Brien KD, Allen M D, McDonald T O, Chait A, Harlan J M, Fishbein D, McCarty J, Ferguson M,
Hudkins K, Benjamin C D. 1993. Vascular cell adhesion molecule-1 is expressed in human coronary
atherosclerotic plaques. Implications for the mode of progression of advanced coronary
atherosclerosis. J Clin Invest 92:945951
Okushi I. 1954. Experimental studies on the effectsof sodium fluoride upon the heart muscle of
rabbits. Abstracted from Shikoku Acta Medica 5:238-45 (cited by Blank 2012).
Okushi I. 1954a. Changes in the heart muscle due to chronic fluorosis. Part I: Electrocardiogram and
cardiac x-rays in inhabitants of a high fluoride zone. (Abstracted from) Shikoku Acta Medica 5:159-
Okushi I. 1954b. Changes in the heart muscle due to chronic fluorosis. Part II: Experimental studies
on the effects of sodium fluoride upon the heart muscle of rabbits. (Abstracted from) Shikoku Acta
Medica 5:238-45.
Opie L H and Hesse B. 1997. Radionuclide tracers in the evaluation of resting myocardial ischaemia
and viability. European Journal of Nuclear Medicine 24(9) 1183-1193. *
Osmunson B and Adams A. 2015. Nomination to the National Toxicology Program. For the Office of
the Report on Carcinogens: Fluoride.
Pacauskiene I, Kopustinskiene D, PaipalieneP, Sadzeviciene R. 2009. Effect of fluoride on the
respiration rate of rat cardiac mitochondria. Fluoride.42(3):198202.
Pain G N. 2015a. Fluoride doped Hydroxyapatite in Soft Tissues and Cancer A Literature Review.
Pain G N. 2015b. Fluoride is a bio-accumulative, endocrine disrupting, neurotoxic carcinogen not a
nutrient. https://www.researchgate.net/publication/285771633_Fluoride_is_a_bio-
Pain G N. 2015c. Plumbosolvency exacerbated by Water Fluoridation.
Pain G N. 2015d. Fluoride Causes Diabetes.
Pandi-Perumal S R, V Srinivasan, G J M Maestroni, D P Cardinali, B Poeggeler and Hardeland R. 2006.
Melatonin Nature’s most versatile biologicalsignal? FEBS Journal 273, 28132838
Panneerselvam L, Govindarajan V, Ameeramja J, Raveendran Nair H and Perumal E. 2015.Single oral
acute fluoride exposure causes changes in cardiacexpression of oxidant and antioxidant enzymes,
apoptotic and necrotic markers in male rats. Biochimie 119, 27-35.
Partanen S. 2005, Localisation of high acid phosphotyrosine phosphatase activity in afferent
arterioles and glomeruli of human kidney, Journalof Molecular Histology 36(4) 225-233. *
Pribilla O. 1968. Four cases of acute silicofluoride intoxication: clinical and pathological findings.
Fluoride 1:102-9.
Prystupa J. 2011. Fluorine - A current literature review. An NRC and ATSDR based review of safety
standards for exposure to fluorine and fluorides. Toxicology Mechanisms and Methods 21(2): 103
Queensland Hospital Admitted Patient Data Collection 2005-2006 prepared by Health Surveillance,
Tropical Population Health Network
Qu QQ, Shen YL, Liu KT, Zhong JJ. 2009. Experimental study on rat cardiac toxicity induced by sodium
fluoride of different dosages. Endemic Diseases Bulletin. 24(2):4-6
Ramos CL, Huo Y, Jung U, Ghosh S, Manka DR, Sarembock IJ, Ley K. 1999. Direct demonstration of P-
selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of
apolipoprotein E-deficient mice. Circ Res. Jun 11;84(11):1237-44
Rodondi N, den Elzen WP, Bauer DC, Cappola AR,Razvi S, Walsh JP, Asvold BO, Iervasi G, Imaizumi
M, Collet TH, Bremner A, MaisonneuveP, Sgarbi JA, Khaw KT, Vanderpump MP, Newman AB, Cornuz
J, Franklyn JA, Westendorp RG, Vittinghoff E, Gussekloo J. Collaborators Olson J, Kronmal R, Robbins
J, Chaves PH, Burke G, Kuller LH, Tracy R, Gottdiener J, Prineas R, Becker JT, Enright P, Klein R,
O'Leary DH. 2010. Subclinical hypothyroidism and therisk of coronary heart disease and mortality.
JAMA 304(12):1365-74
Rumberger JA, Simons DB, Fitzpatrick LA, SheedyPF, Schwartz RS. 1995. Coronary artery calcium
area by electron-beam computed tomography and coronary atherosclerotic plaque area: a
histopathologic correlative study. Circulation 92:21572162
Sauerheber S. 2013. Physiologic Conditions AffectToxicity of Ingested Industrial Fluoride. Journal of
Environmental and Public Health.
Sauerheber S. 2014. Racehorse Breakdowns and Artificially Fluoridated Water In Los Angeles.
Fluoride 46(4)170179
Scheer FA, Kalsbeek A, Buijs RM. 2003. Cardiovascularcontrol by the suprachiasmatic nucleus:
neural and neuroendocrine mechanisms in human and rat. Biol Chem 384:697-709
Scheer FA, Van Montfrans GA, Van Someren EJ, Mairuhu G and Buijs RM. 2004. Daily night-time
melatonin reduces blood pressure in male patients with essential hypertension. Hypertension43,
Schieffer B, Selle T, Hilfiker A, Hilfiker-Kleiner D, Grote K, Tietge UJF, Trautwein C, Luchtefeld M,
Schmittkamp C, Heeneman S, Daemen MJAP, Drexler H. 2004. Impact of interleukin-6 on plaque
development and morphology in experimental atherosclerosis. Circulation. Nov 30;110(22):3493-
Shashi A, Thapar SP. 2001. Histopathology ofmyocardial damage in experimental fluorosis in rabbits.
Fluoride 34(1):43-50.
Singh A, Jolly SS, Bausal BC. Skeletal Fluorosis and its Neurological Complications. The Lancet ; 197-
200, January 28, 1961
Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D,
Field L, Firulli AB, Molkentin JD, MarkwaldR, Conway SJ. 2008. Periostin is required for maturation
and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res. 2008 Apr
Song A H, Wang T, Jiang C, Zhang Z, Wang Z. 1990. Observations on fluorotic aortosclerosis bytwo-
dimensional echocardiography. Endemic Diseases Bulletin 5(1): 91-94. Translation available.
Stary H C. 2000. Natural history of calcium deposits in atherosclerosis progression and regression. Z
Kardiol 89 Suppl 2:2835.
Stookey G K, Muhler J C. 1963. Relationship between fluoride deposition and metastatic calcification
in soft tissues of rat and guinea pig. Proceed Soc Exp Biol Med 113:720-5.
Streeten D H P, Anderson G H Jr, Howland T, Chiang R, and Smulyan H. 1988. Effects of Thyroid
Function on Blood Pressure Recognition of Hypothyroid Hypertension. Hypertension 11, 78-83
(Journal of the American Heart Association)
Susheela AK, Kharb P. 1990. Aortic calcification inchronic fluoride poisoning: biochemical and
electronmicroscope evidence. Exp Mol Path53:72-80.
Suzuki M, Bandoski C and Bartlett J D. 2015. Fluoride induces oxidative damage and
SIRT1/autophagy through ROS-mediated JNK signalling. Free Radical Biology and Medicine. 89, 369-
Takamori T, Miyanaga S, Kawahara H, Okushi I, Hirao, Wakatsuki, H. 1956. Electrocardiographic
studies of the inhabitants in high fluoride districts. Fluoride 4(4):204-9.
Takamori T, Miyanaga S, Kawahara H, Okushi I, Hirao, Wakatsuki, H. 1956. EKG studies of inhabitants
in high fluoride areas, Tokushima Journal of Experimental Medicine 3:50
Tanigami H, Yahagi N, Kumon K, Watanabe Y,Haruna M, Matsui J and Hayashi H. 1997. Long-term
sedation with isoflurane in postoperative intensive care in cardiac surgery. Artificial Organs vol. 21(1)
Tartatovskaya LY, Samokhvalova GN, Antropov AG. 1995. Clinico-hygiene assessment of the
combined effect on the body of vibration and fluorine. Noise and Vibration Bulletin pp 263-264
(from: Meditsina Truda i Promyshlennaya Ekologiya 10:8-10). Translation available at
Tomazic, B B. 2001. Physiochemical principlesof cardiovascular calcification. Zeitschrift fur
Kardiologie 90 Suppl(3) 68-80. *
Trion A, van der Laarse A. 2004. Vascular smoothmuscle cells and calcification in atherosclerosis. Am
Heart J 147:808814
Tuncel E. 1984. The incidence of Moenckeberg calcifications in patients with endemic fluorosis.
Fluoride 17(1):4-8.
Tyagi S C, Kumar S G, Haas S J, Reddy H K, Voelker D J, Hayden M R, Demmy T L, Schmaltz R A, and
Curtis J J. 1996. Post-transcriptional regulation of extracellular matrix metalloproteinase in human
heart end-stage failure secondary to ischemic cardiomyopathy. Journal of Molecular and CellularCardiology 28(7) 1415-1428.
UC Davis UC Davis School of Veterinary Medicine, Postmortem Examination Program 2012. Available
from: http://www.chrb.ca.gov/annual_reports/2010-11_post_mortem_annual_report.pdf
US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances
and Disease Registry. Toxicological profile for fluorides, hydrogen fluoride, and fluorine. Atlanta, GA:
US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances
and Disease Registry; 2003. Available from:http://www.atsdr.cdc.gov/toxprofiles/tp11.pdf
Varol E, Akcay S, Ersoy IH, Koroglu BK, Varol S. 2010a.Impact of chronic fluorosis on left ventricular
diastolic and global functions. Sci Tot Environ 408:2295-8.
Varol E, Akcay S, Ersoy IH, Ozaydin M, Koroglu BK, Varol S. 2010b. Aortic elasticity is impaired in
patients with endemic fluorosis. Biol Trace Elem Res 133:121-7.
Varol E, Akçay S, Ersoy YE, Özaydyn M, Koroglu BK,Varol S. 2010c. Electrocardiographic evaluation in
patients with endemic fluorosis without clinically evident heart disease. S.D.Ü. Typ Fak. Derg.
Varol E, Varol S. 2012. Effect of fluoride toxicity on cardiovascular systems: role of oxidative stress.
Arch Toxicol (Letter to the Editor) 86(10) 1627.
Waldbott GL. 1966. Fluoride and calcium levels in theaorta. Specialia 15:835-6.
Walland A. 1977. Further evidence for the involvement of cAMP in central blood pressure regulation.
Arch Pharmacol 296:177-81.
Wang F, Zhang, D, and Wang, R, Toxic effects of fluoride on beating myocardial cells cultured in vitro.
Fluoride 31(1):26-32, 1998
Wang L, Jerosch-Herold M, Jacobs DR Jr, Shahar E,Detrano R, Folsom AR. 2006. Coronary artery
calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of
Atherosclerosis). J Am Coll Cardiol 48:10181026
Wang Y, Zhu M, Zhang X, Gu W, Wang Y, Duan R, AnD, Li X, Zhu W, Song S. 1988. A comparative
study on systolic time interval of populations inmild and severe endemic fluorosis regions. Chin J
Endem 7(1) 4-6
Waugh D. 2013. Fluoride and Cardiovascular Disease: Case Study on Implications for Public Health in
Waugh D. 2016. In press.
Weber LP, Chow WL, Abebe W, MacLeod KM. 1996. Enhanced contractile responses of arteries from
streptozotocin diabetic rats to sodium fluoride. Br J Pharmacol. May 118(1):115-22.
Weiss N, Keller C, Hoffman U, Loscalzo J. 2002. Endothelial Dysfunction and Atherothrombosis in
mild Hyperhomocysteinemia. Vasc Med; 7:227-239.
Williams G, Kolodny GM. 2009. Retrospectivestudy of coronary uptake of 18 F-fluorodeoxyglucose
in association with calcification and coronary artery disease: a preliminary study. Nucl Med Commun
Wykrzykowska J, Lehman S, Williams G,Parker JA, Palmer MR, Varkey S, Kolodny G, Laham R. 2009.
Imaging of inflamed and vulnerable plaque in coronary arteries with 18 F-FDG PET/CT in patients
with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation. J Nucl Med;
50: 563568.
Xu H, Jin X-Q, Jing L and Li G-S. 2006. Effect of sodium fluoride on the expression of Bcl-2 family and
osteopontin in rat renal tubular cells. BiologicalTrace Element Research 109:55-60.
Xu RY, Xu RQ. 1997. Electrocardiogram analysis of patients with skeletal fluorosis. Fluoride 30(1):16-
8. *
Yang E, Jeon S B, Baek I, Song M J, Yoon Y R and Kim I K. 2010. Fluoride induces vascular contraction
through activation of RhoA/Rho kinase pathway in isolated rat aortas. Environmental Toxicology and
Pharmacology. 29(3) 290296
Yang E, Cho JY, Sohn UD, Kim IK. 2010. Calcium sensitization induced by sodium fluoride in
permeabilized rat mesenteric arteries. Korean J Physiol Pharmacol. Feb 14(1):51-7
Yaprak M, Altun A, Vardar A, Betul UA, Ozbay G. 2003. Decreased nocturnal synthesis of melatonin
in patients with coronary artery disease. Int J Cardiol 89:103-7
Zhang J, Zhang Z. 2013. Effects of chronic fluorosis on CAMKIIA, C-FOS, BAX, and BCL-2 channel
signalling in the hippocampus of rats. Fluoride July-September 46(3)135141
Zipkin I, McClure FJ, Leone KC, Lee W. 1958. Fluoride deposition in human bones after prolonged
ingestion of fluoride in drinking water. US Public Health Rep 73:732-740.

Endocrine disruption by Fluoride is well known and reported by the World Health Organization

I have summarized some key literature


Akiniwa, K. 1997. Re-examination of the acute toxicity of Fluoride. Fluoride 30(2) 89-104
Australian Government. 2015. Department of Health. Methodological framework for the review of
Nutrient Reference Values.
Belgium 2002. Belgian Council for Hygiene scientific opinion.
Bergman, Åke, Heindel, Jerrold J, Jobling, Susan, Kidd, Karen A and Zoeller, R Thomas. Editors 2013
State of the Science of Endocrine Disrupting Chemicals 2012 An assessment of the state of the
science of endocrine disruptors prepared by a group of experts for the United Nations Environment
Programme and World Health Organization.
Choi, A.L., Zhang Y., Sun, G., Bellinger, D.C., Wang, K., Yang, X.J., Li, J.S., Zheng, Fug, Q.Y., Grandjean,
P. 2015. Association of lifetime exposure to fluoride and cognitive functions in Chinese children: A
pilot study. Neurotoxicology and Teratology. Volume47, 96101.
Connett, E and Connett, P. 2002. Submission to the ATSDR.
Connett, P., Beck, J., Micklem, H.S., The Case Against Fluoride, How Toxic Waste Ended up in our
Drinking Water and the Bad Science and Politics thatKeep it There, Chelsea Green Publishing, White
River Junction, VT, USA, 2010.
Connett P. et al. 2015. Fluoride Action Network database. www.fluoridealert.org.
Deal, J.R. 2015. National Sanitation Foundation Sham FDA Fraudulent Certifier of Fluoridation
Materials. Available from Research Gate.
Diesendorf, M. 1990. The health hazards of fluoridation: a re-examination, International Clinical
Nutrition Review 10(2) 304-321
Diesendorf M. 2006. Skeptic, Winter edition. Fluoridation: Unsafe, Ineffective and Unethical pp. 61-
63, 68.
EFSA Panel on Dietetic Products, Nutrition andAllergies 2013: Carlo Agostoni, Roberto Berni Canani,
Susan Fairweather-Tait, Marina Heinonen, HannuKorhonen, Sébastien La Vieille, Rosangela
Marchelli, Ambroise Martin, Androniki Naska, Monika Neuhäuser-Berthold, Grażyna Nowicka,
Yolanda Sanz, Alfonso Siani, Anders Sjödin, MartinStern, Sean (J.J.) Strain, Inge Tetens, Daniel Tomé,
Dominique Turck and Hans Verhagen. Scientific opinion on Dietary Reference Values for Fluoride.
EFSA Journal 11(8) 3332
FSANZ. Food Standards Australia and New Zealand. 2012. The 23rd Australian Total Diet Study.
International Association of Oral Medicine and Toxicology. 2003. Policy position on ingested fluoride
and fluoridation.
Kennedy D. 2015. personal communication
Ko, L. and K. Thiessen. 2015. A critique of recent economic evaluations of community water
fluoridation. International Journal of Occupational and Environmental Health 21, 91-120
Li, S., Smith, K.D., Davis, J.H., Gordon, P.B., Breaker, R.R. and S.A. Strobel. 2013. Eukaryotic resistance
to fluoride toxicity mediated by a widespread family of fluoride export proteins. Proceedings of the
National Academy of Sciences. 110(47) 19018-19023
Lovering, E.M. 1963. Consumer Inquiries Section, USFDA to N.M. Wellesley, Mass. 8/15/63
MacArthur, J.D. 2015. Fluoride, Premature Birth and Impaired Neurodevelopment
Malin, A. and C.Till. 2015. Exposure to fluoridated water and attention deficit hyperactivity disorder
prevalence. Environmental Health 14, 17
Marshall T.A. et al. 2004. Associations between Intakes of Fluoride from Beverages duringInfancy
and Dental Fluorosis of Primary Teeth. Journal of the American College of Nutrition 23, 108-16
Maurer and Day. 1957. The Non-Essentiality of Fluoride in Nutrition. Journal of Nutrition, 62, 561-
Needham, B. 2010. “Killer Smile” Report to Minister for Health and Human Services. Water
Fluoridation and Ill Health of at Risk Groups in the Tasmanian Population in 2010.
National Research Council. 1993. Health Effects ofIngested Fluoride. National Academy Press,
Washington DC. p. 30
NHMRC 2007 Part B. Excluded Studies. 355 pages.
Pain, G. October 2015a. Fluoride doped Hydroxyapatite in Soft Tissues and Cancer A Literature
Review. Available from Research Gate.
Pain, G. 2015b. Fluoride Causes Diabetes. Availablefrom Research Gate.
Pain, G. 2015c. NHMRC = Politics, Not Science. Australians Victims of Dangerous Fluoridation
Experiments. Available from Research Gate.
Pain, G. 2015d. Plumbosolvency exacerbated by Water Fluoridation. Available from Research Gate.
Peckham, S. Lowery, D. and S Spencer. 2015. Are fluoride levels in drinking water associated with
hypothyroidism prevalence in England? A largeobservational study of GP practice data and fluoride
levels in drinking water. J Epidemiol Community Health. pp 1-6.
Queensland Government Workplace Health and Safety. 2015. Fluoride health monitoring guidelines.
Sauerheber, R. 2013. Physiologic Conditions Affect Toxicity of Ingested Industrial Fluoride. Journal of
Environmental and Public Health Volume 2013
Saul, A.W. 2012. Dispensing with Fluoride. Orthomolecular Medicine News Service 7 May Editorial.
SCHER 2011. The Scientific Committee on Health and Environmental Risks. Critical review of any new
evidence on the hazard profile, health effects, and human exposure to fluoride and the fluoridating
agents of drinking water.
Stanton, R. 2015. personal communication.
Stockbridge, R.B., Kolmakova-Partensky, L., Shane,T., Koide, A., Koide, S., Miller, C. and S. Newstead.
2015. Crystal structures of a double-barrelled fluoride ion channel. Nature, 525, 548-551
Sutton, M., Kiersey, R., Farragher, L. and Long, J.2015. Health effects of water fluoridation.
U.S. Food and Drug Administration. 2006. Health Claim Notification for Fluoridated Water and
Reduced Risk of Dental Caries. Center for Food Safety and Applied Nutrition. Office of Nutritional
Products, Labeling, and Dietary Supplements,October 14, 2006
USPHS. 1966. Department of Health, Education andWelfare. Letter signed by Robert W Bonds.
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J.J., Jacobs, D. R., Lee, D. H., Shioda, T., Soto, A.
M., vom Saal, F. S., Welshons, W. V., Zoeller, R. T.,Myers, J. P. 2012. Hormones and endocrine-
disrupting chemicals: Low dose effects and nonmonotonic dose responses. Endocrine Reviews, 33(3)
Verkerk R. 2010. The paradox of overlapping micronutrient risks and benefits obligates risk/benefit
analysis, Toxicology 278(1) 2738
Wilson, G. H. III et al. 2014. An Approach to Breast Cancer Diagnosis via PET Imaging of
Microcalcifications Using 18F-NaF. The Journal of Nuclear Medicine (7) 1138-1143
World Health Organization 2014. Regional Assessment Report. Chemicals of Public Health Concern
and their management in the African Region.
Xiang Q, et al. 2003. Effect of fluoride in drinking water on children’s intelligence. Fluoride 36: 84-94.
Yazahmeidi, B and D’Arcy J. Holman, C. 2007. A surveyof suppression of public health information by
Australian governments. Aust N Z J Public Health. 31 (5) 51-7




It is well known that Fluoridation chemicals increase the dissolution of Lead from pipes, including PVC, solder and brass fittings used in the water supply distribution network and household. It is alos known that ceasing Fluoridation will reduce the concentration of Lead in drinking water giving health benefits that far outway imagined reduction of tooth decay.


I have reviewed the subject here: https://www.researchgate.net/publication/282439972_Plumbosolvency_exacerbated_by_Water_Fluoridation


Allegood, J. 2005. Water treatment process called potential risk. Chemicals’ mix with plumbing could put lead in tap water. The News & Observer. May 18, 2005 [online]. Available: http://www.newsobserver.com/news/health_science/story/2417101p-8794959c.html
Auckland Healthcare Services. 2008. What is Plumbosolvency and are there any Health Risks?
Bonomi A, et al. 2001. Selective deleading process and bath for plumbing components made of a copper alloy. US Patent 6,284,053; September 4, 2001.
Borodin, PM, Zao, NGK and NS Petrov. 1974. Stability of the hexafluorosilicate ion in aqueous solutions of fluorosilicic acid, from19F NMR dataJournal of Structural Chemistry 14(4) 564-568
Burt, J, Grantham, W, Levason, W, Light, M E and Reid, G. 2015. Hexafluorosilicate and tetrafluoroborate coordination to lead(II) di- and tri-imine complexes – Unusual fluoroanion coordination modes. Polyhedron, 85, 530-36
Burt, J, Grantham, W, Levason, W and Reid. 2015. Lead(II) nitrate and hexafluorosilicate complexes with neutral diphosphine coordination Dalton Transactions , 244, 11533
Clabby, C. 2005. Water tests to plumb extent of lead problem. Durham among cities where chemical could cause toxic taint in tap water. The News and Observer, Raleigh, NC, September 3 [online]. Available: http://www.newsobserver.com
Cole ER Jr., et al. 1981. Electrowinning of lead from H2SiF6 solution. US Patent 4,272,340; June 9
Coplan MJ, Patch SC, Masters RD, Bachman MS. 2007.Confirmation of and explanations for elevated blood lead and other disorders in children exposed to water disinfection and fluoridation chemicals. Neurotoxicology. Sep; 28(5):1032-42. Epub Mar 1
Comber, S, Cass , F, Brown, B, Martin, J, Hillis, P and Gardner, M. 2011. Phosphate treatment to reduce plumbosolvency of drinking water also reduces discharges of copper into environmental surface waters. Water Environ. J. 25, 266−270.
Conley, DC, Yearwood BC, Parkin S and Atwood DA. 2002. Ammonium hexafluorosilicate salts. Journal of Fluorine Chemistry 115, 155-160
CRC Handbook of Chemistry and Physics 57th Edition.
Dabeka, RW, Karpinski, KF McKenzie, AD and CD Bajdik. 1986. Survey of lead, cadmium and fluoride in human milk and correlation of levels with environmental and food factors. Food Chem. Toxicol. 24(9):913-921.
Dabeka, RW, and AD McKenzie. 1987. Lead, cadmium, and fluoride levels in market milk and infant formulas in Canada. J. Assoc. Off. Anal. Chem. 70(4):754-757.
Dabeka, RW, and AD McKenzie. 1995. Survey of lead, cadmium, fluoride, nickel, and cobalt in food composites and estimation on dietary intakes of these elements by Canadians in 1986-1988. J. AOAC Int. 78(4):897-909.
Dudi A, Schock M, Murray N, Edwards M. 2005. Lead leaching from inline brass devices: a critical evaluation of the existing standard. J Am Water Works Assoc 97(8):66–78.
Edwards M, McNeill LS. 2002. Effect of phosphate inhibitors on lead release from pipes. J Am Water Works Assoc;94(1):79–92

Edwards, M, Triantafyllidou, S, Best, D. 2009. Elevated blood lead in young children due to lead-containing drinking water. Environ. Sci. Technol. 43, 1618−1623.
Edwards, M. 2014. Fetal death and reduced birth rates associated with exposure to lead-contaminated drinking water. Environ. Sci. Technol. 48, 739−746.
European Commission. 2010. Critical review of any new evidence on the hazard profile, health effects, and human exposure to fluoride and the fluoridating agents of drinking water.
Finney WF, Wilson E, Callender A, Morris MD, Beck LW, 2006, Reexamination of Hexafluorosilicate Hydrolysis by 19F NMR and pH Measurement, Environ. Sci. Technol., 40 (8), pp 2572–2577
Glemboldt, VO, Ganin VE, Fonaria MS, Simonov, YA, Koroeva, YA, Enna AA, Basok SS, Shova, S, Kahlig, H, Arion, VB and Keppler BK. 2007. Two new “onium” fluorosilicates, the products of interaction of fluorosilicic acid with 12-membered macrocycles: structures and spectroscopic properties. Dalton Transactions. 2915-2924
Gooch, BF. 2015. U.S. Public Health Service Recommendation for Fluoride Concentration in Drinking Water for the Prevention of Dental Caries. Public Health Reports / July–August 2015 / Volume 130, 1-14
Gooddy, Daren C, Lapworth, Dan J, Ascott, Matthew J, Bennett, Sarah A, Heaton Timothy H E, and Ben W J Surridge 2015. Isotopic Fingerprint for Phosphorus in Drinking Water Supplies Environ. Sci. Technol. 49, 9020−9028
Hac, E, Czarnowski, Gos, T and J Krechniak. 1997. Lead and fluoride content in human bone and hair in the Gdansk region. Sci. Total Environ. 206(2-3):249-254.
Hayes, CR and Croft, TN. 2014. Optimisation of plumbosolvency control using computational modelling techniques: a demonstration project for the Government of Alberta, working with the city of Calgary and EPCOR (Edmonton).
Holman, I P, Whelan, M J, Howden, N J K, Bellamy, P H, Wilby, N J, Rivas-Casado, M, McConvey, P. 2008. Phosphorus in groundwater - An overlooked contributor to eutrophication. Hydrol. Processes 22, 5121−5127.
Jackson PJ and JC Ellis. 2003. Report DWI 6173 Demonstration of Optimisation of Plumbosolvency Treatment and Control Measures. Final Report to the Drinking Water Inspectorate
Kennedy, David C. D.D.S 2003 IAOMT Policy position on ingested fluoride and fluoridation
Langphear, B P, Hornung, R, Khoury, J, Yolton, K, Baghurst, P, Bellinger, D C, Canfield, R L, Dietrich, K N, Bornschein, R, Greene, T, Rothenberg, S J, Needleman, H L. Schnaas, L, Wasserman, G, Graziano, J, Roberts, R. 2005. Low-level environmental lead exposure and children’s intellectual function: An international pooled analysis. Environ. Health Perspect. 113, 894−899.
Leite GAS, Sawan RMM, Teofilo JM, Porto IM, Sousa FB, Gerlach RF. 2011. Exposure to lead exacerbates dental fluorosis. Arch Oral Biol 56(7):695-702.
Luo G, Niu R, Sun Z, Zhang J, Wang J, Wang C, Wang J. 2011. Reduction of CAMKII expression in the hippocampus of rats from ingestion of fluoride and/or lead. Fluoride April-June 44(2):63–69
Maas, RP, Patch, SC and AM Smith. 2005. Effects of Fluorides and Chloramines on Lead Leaching from Leaded-Brass Surfaces. Technical Report 05-142. Environmental Quality Institute, University of North Carolina, Asheville, NC. June
Maas, R P, Patch, S C, Christian, A and Coplan, M J. 2007 Effects of fluoridation and disinfection agent combinations on lead leaching from leaded-brass parts NeuroToxicology 28, 1023–1031
Macek, MD, Matte, TD Sinks, T and DM Malvitz. 2006. Blood lead concentrations in children and method of water fluoridation in the United States, 1988-1994. Environ. Health Perspect. 114(1):130-134.

Mahaffey, KR et al 1976. Effect of High Fluorine (F) intake on tissue lead (Pb) Concentrations. Fed. Proc., 35, 256.
Mann, Judy. 2000. Chemicals and Crime: A Truly Toxic Effect by, May 26, page C 11, Washington Post
Masters, R D and M J Coplan. 1999. Water Treatment With Silicofluorides and Lead Toxicity, by International Journal of Environmental Studies, 56. pp. 435-449
Masters, R D. 2004. The Hidden Handicap: Lead, Brain Chemistry, and Educational Failure. Paper presented to 2004 Annual Meeting of the American Political Science Association, Chicago, IL., Sept. 3.
Masters RD, Coplan MJ, Hone BT, Dykes JE. 2000. Association of silicofluoride treated water with elevated blood lead. Neurotoxicology 21(6):1091-100.
Miranda ML, Kim D, Hull AP, Paul CJ, Galeano MAO. 2006 Changes in blood lead levels associated with use of chloramines in water treatment systems. Environ. Health Perspect. http://dx.doi.org/; online November 7.
Mullenix, P et al. 1995. Neurotoxicity of Sodium Fluoride in Rats, Neurotoxicology and Teratology, 17, No. 2, pp. 169-177
Niu, R, Sun, Z, Cheng, Z, Liu, H and Chen H. 2008. Effects of fluoride and lead on N-methyl-D-aspartate receptor 1 expression in the hippocampus of offspring rat pups Fluoride April-June 41(2):101-110
Niu, R, Sun, Z, Wang, J, Cheng, Z and Wang J. 2008. Effects of fluoride and lead on locomotor behavior and expression of nissl body in brain of adult rats. Fluoride October-December 41(4):276–282
Niu, R, Sun, Z, Cheng, Z, Li,Zand Wang J. 2009. Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead. Environmental Toxicology and Pharmacology September 28(2):254-8.
Pocock, S J, Shaper, A G, Ashby, H T, Dewes, H T and Clayton, B E. 1988. The relationship between blood lead, blood pressure, stroke and heart attacks in middle-aged British men. Environ. Health Perspect. 78, 23−30.
Rice JR, Boyd WA, Chandra D, Smith MV, Den Besten PK, Freedman JH. 2014. Comparison of the toxicity of fluoridation compounds in the nematode Caenorhabditis elegans Environmental Toxicology and Chemistry January 33(1):82-8.
Switzer JA, Rajasekharan VV, Boonsalee S, Kulp EA, Bohannan EW. 2006. Evidence that monochloramine disinfectant could lead to elevated Pb Levels in drinking water. Environ Sci Technol 40:3384–7.
UK Water Industry Research Limited. 2011. Alternatives to Phosphate for Plumbosolvency Control
Xiang Q, et al. 2003a. Effect of fluoride in drinking water on children’s intelligence. Fluoride 36: 84-94.
Xiang Q, et al. 2003b. Blood lead of children in Wamiao-Xinhuai intelligence study. Fluoride 36: 198-199




Diabetes is caused by Fluoride

I have reviewed the subject here: https://www.researchgate.net/publication/273442062_Fluoride_Causes_Diabetes


Note: Those marked * were deliberately excluded from the NMRC 2007 Review.
Alavi, A A, Amirhakimi, E and Karami, B. 2006 The prevalence of dental caries in 5-18-year-old insulin-dependent diabetics of Fars Province, southern Iran Archives of Iranian Medicine, 9( 3) 254-260 *
Australian Health Ministers’ Advisory Council (AHMAC) Steering Committee for National Planning for Oral Health 2001 Oral health of Australians: National planning for oral health improvement: Final report. South Australian Department of Human Services.
Avtsyn, A P and Zhavoronkov, A A. Fluorosis pathology (Novosibirsk, 1981) cited in Tokar 1992.
Banu Priya C A Y, Anitha K, Murali Mohan E, Pillai K S and Murthy P B. 1997. Toxicity of fluoride to diabetic rats. Fluoride 30(1) 43-50.
Basha M P, Saumya S M. 2013 Influence of fluoride on streptozotocin induced diabetic nephrotoxicity in mice: Protective role of Asian ginseng (Panax ginseng) & banaba (Lagerstroemia speciosa) on mitochondrial oxidative stress The Indian Journal of Medical Research February 137(2) 370–379
Bergman, Åke, Heindel, Jerrold J, Jobling, Susan, Kidd, Karen A and Zoeller, R Thomas. Editors 2013 State of the Science of Endocrine Disrupting Chemicals – 2012 An assessment of the state of the science of endocrine disruptors prepared by a group of experts for the United Nations Environment Programme and World Health Organization.
Birkner E, Grucka-Mamczar E, Zalejska-Fiolka J et al. 2006. Influence of sodium fluoride and caffeine on the concentration of fluoride ions, glucose, and urea in blood serum and activity of protein metabolism enzymes in rat liver. Biol Trace Elem Res. 112(2) 169-74.
Bolgul, B S, Celenk, S, Ayna, B E, Atakul, F and Uysal, E. 2004 Evaluation of caries risk factors and effects of a fluoride-releasing adhesive material in children with insulin-dependent diabetes mellitus (IDDM): Initial first-year results Acta Odontologica Scandinavica, 62(5) 289-292. *
Boros, I, Keszler, P, Csikós G and Kalász H. 1998 Fluoride intake, distribution, and bone content in diabetic rats consuming fluoridated drinking water. Fluoride 31(1) 33-42
Cettour-Rose, P, Theander-Carrillo, C , Asensio, C, Klein, M, Visser, T J, Burger, A G, Meier C A, and Rohner-Jeanrenaud F. 2005. Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion. Diabetologia 48(4) 624-633 cited in NRC 2006.
Chang, C H, Tsai, R K, Wu, W C, Kuo, S L, and Yu, H S. 1997 Use of dynamic capillaroscopy for studying cutaneous microcirculation in patients with diabetes mellitus. Microvascular Research 53 121-127 *
Chehoud, K A, Chiba, F Y, Sassaki, K T, Garbin, C A, Sumida, D H. 2008 Effects of fluoride intake on insulin sensitivity and insulin signal transduction Fluoride October-December 41(4) 270–275
Chiba F Y, Colombo N H, Shirakashi D J, Da Silva V C, Moimaz S A S, Garbin C A S, Antoniali C and Sumida D H. 2012 NaF treatment increases TNF-a and resistin concentrations and reduces insulin signal in rats. Journal of Fluorine Chemistry 136 3–7
Chiba, F Y, Garbin, C A S, Sumida, D H. 2012 Effect of fluoride intake on carbohydrate metabolism, glucose tolerance, and insulin signaling. Fluoride July-September 45(3 Pt 2) 236–241
Chiba, F Y, Colombo, N H, Shirakashi, D J, Gomes, W D, Moimaz, S A S, Garbin, C A S, Silva, CA and Sumida, D H. 2010 Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride. Fluoride January-March 43(1)25–30
Chlubek D et al. 2003 Activity of pancreatic antioxidative enzymes and malondialdehyde concentrations in rats with hyperglycemia caused by fluoride intoxication. J. Trace Elem. Med. Biol. 17 57-60.

Cohen, B Z, Wald, K J, and Toyama, K. 1997 Neodymium:YLF picosecond laser segmentation for retinal traction associated with proliferative diabetic retinopathy, American Journal of Ophthalmology, 123 (4) 515-523 *
Cortet, B, Berniere, L, Solau-Gervais, E, Hacene, A, Cotten, A, and Delcambre, B. 2000, “Axial osteomalacia with sacroiliitis and moderate phosphate diabetes: Report of a case”, Clinical and Experimental Rheumatology, 18 (5) 625-628.
de la Sota, M, Puche, RC, Rigalli, A, Fernandez, L M, Benassati, S and Boland, R 1997 Modificaciones en la masa o´sea y en la homeostasis de la glucose en residentes de la zona de Bahia Blanca con alta ingesta esponta´nea de flu´ or. Medicina 57 417–420
De Valk H W. 1999 Magnesium in diabetes mellitus. Neth J Med 54 139–46
Dunipace A J, et al. 1996. Absence of detrimental effects of fluoride exposure in diabetic rats. Archives of Oral Biology 41(2) 191-203
García-Montalvo E A, Reyes-Pérez H, Del Razo L M. 2009 Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress. Toxicology September 19 263(2-3) 75-83
Greenberg L W, Nelsen C E, Kramer N. 1974. Nephrogenic diabetes insipidus with fluorosis. Pediatrics 54 320–322
Grucka-Mamczar E, et al. 2004 Activities of some enzymes and concentration of ammonia in serum of rats with fluoridehyperglycemia Ann Acad Med Stetin. 50 Suppl 1 36-41.
Gutowska I, Baranowska-Bosiacka I, Rybicka M, Dudzinska W, Marchlewicz M, Nocen I, Sawinski G, Wiszniewska B, Chlubek D. 2009 Changes in the concentration of fluoride in the serum and bones of female rats with streptozotocin induced diabetes. Fluoride January-March 42(1) 9–16
Hanhijarvi H, Penttila I, Pekkarinen A, Hakulinen A. 1974 The effect of age on free ionized plasma fluoride concentrations in patients from Artificially Fluoridated and Non-fluoridated Drinking Water Communities. Proc Finn Dent Soc. 3 25–34.
Hattori Y, Matsuda N, Sato A, Watanuki S, Tomioka H, Kawasaki H, Kanno M. 2000 Predominant contribution of the G protein-mediated mechanism to NaF-induced vascular contractions in diabetic rats: association with an increased level of G(qalpha) expression. J Pharmacol Exp Ther. 292(2) 761-8.
Henderson, Michelle 28 May 2012 AAP online news http://www.news.com.au/breaking-news/m-have-undiagnosed-kidney-disease/story-e6frfku0-1226368819679
Hu C Y, Ren L Q, Li X N, Wu N, Li G S, Liu Q Y, Xu H. December 2012 Effect of fluoride on insulin level of rats and insulin receptor expression in the MC3T3-E1 cells. Biological Trace Element Research 150(1-3) 297-305
Irmak, M K, Ozcelik, I S, Kaya, A. 2014 Fluoride toxicity and new-onset diabetes in Finland: a hypothesis Journal of Experimental and Integrative Medicine 4(1) 3-8.

Kathpalia, A and Susheela, A K. 1978, Effect of sodium fluoride on tissue protein in rabbits Fluoride 12 125–129. Cited in Tokar 1992
Klein, H. 1975. Dental fluorosis associated with hereditary diabetes insipidus. Oral Surg. Oral
Med. Oral Pathol. 40(6) 736-741
Lau, K H W, Goodwin, C, Arias M, Mohan S and Baylink D J. 2002 Bone cell mitogenic action of fluoroaluminate and aluminum fluoride but not that of sodium fluoride involves upregulation of the insulin-like growth factor system. Bone 30 705–711
Lin, B I, Henderson, M J, Levine, B B et al. 1976 Horm. Metabo. Res. 8 353–358 cited in Tokar 1992.
Lombarte, Mercedes Fina, Brenda L Lupo, Maela Buzalaf Marı´lia A and Rigalli, Alfredo. 2013 Physical exercise ameliorates the toxic effect of fluoride on the insulin–glucose system Journal of Endocrinology 218 (1) 99-103
Lupo, M, Buzalaf , M A and Rigalli, A. 2011 Effect of fluoridated water on plasma insulin levels and glucose homeostasis in rats with renal deficiency. Biological Trace Element Research 140 198–207
Marier, J R. 1977 Some current aspects of environmental fluoride. Sci . Tot. Environ. 8 253-265.
Matsuoka, T A, Zhao, L, and Stein, R. 2001 The DNA Binding Activity of the RIPE3b1 Transcription Factor of Insulin Appears to Be Influenced by Tyrosine Phosphorylation Journal of Biological Chemistry , 276(25) 22071-22076 *
Mazze R I, Calverley R K, Smith N T. 1977 Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers. Anesthesiology. 46(4) 265-71
Mehta M N, Raghavan K, Gharpure V P, Shenoy R. 1998. Fluorosis: a rare complication of diabetes insipidus. Indian Pediatr 35 463–467
Menoyo, I, Puche, R C and Rigalli, A. 2008 Fluoride-induced resistance to insulin in the rat. Fluoride 41 260–269.
Menoyo I, Rigalli A, Puche R C. 2005 Effect of fluoride on the secretion of insulin in the rat. Arznei-mittel Forschung (Drug Res) 55(5) 455-60.
Michaud D S. 2004 Epidemiology of pancreatic cancer. Minerva Chir, 59(2) 99-111
National Health and Medical Research Council (NHMRC) 2007 A systematic review of the efficacy and safety of fluoridation PART B: EXCLUDED STUDIES
National Research Council 2006 Fluoride in drinking water: A scientific review of EPA's standards. Washington, DC: National Academies Press; 2006. NRC (National Research Council) Report
Ng, C K, Soufer, R and McNulty, P H. 1998 Effect of hyperinsulinemia on myocardial fluorine-18-FDG uptake Journal of Nuclear Medicine, 39(3) 379-383 *
Patel D and Kalhan S. 1975 Glycerol metabolism and triglyceride-fatty acid cycling in the human newborn: effect of maternal diabetes and intrauterine growth retardation. Pediatr Res 31 52–8

PHIDU. 2005 Population health profile of the Townsville Division of General Practice. Population Profile Series: No. 78. Public Health Information Development Unit (PHIDU), Adelaide
Pivonello R, ColaoA, Di Somma C, Facciolli G, Klain M, Faggiano A, Salvatore M, Lombardi G. 1998. Impairment of bone status in patients with central diabetes insipidus. J Clin Endocrinol Metab 83 2275–2280.
Prystupa, J. 2011 Fluorine—A current literature review. An NRC and ATSDR based review of safety standards for exposure to fluorine and fluorides Toxicology Mechanisms and Methods, 21(2) 103–170
Pujary U R, Rao P, Mohanthy S, Krishna R, Reddy D. Correlation between serum fluoride and hyperglycemia in endemic fluorosis area Indian Journal of Clinical Biochemistry December 2007 22(Suppl) 383
Purdie D M, Green A C, 2001. Epidemiology of endometrial cancer. Best Pract Res Clin Obstet Gynaecol, 15(3) 341-354.
Queensland Hospital Admitted Patient Data Collection 2005-2006 prepared by Health Surveillance, Tropical Population Health Network
Rasmussen D D, Boldt B M, Wilkinson C W, Yellon S M and Matsumoto A M 1999 Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels. Endocrinology 140, 1009–1012
Renke W, Winnicka, A and Graczyck M. 1987 Estimation of occupational hazards of the employees of a phosphate fertilizers plant. Bull. Inst. Mar. Trop. Med. Gdynia 38 5-16.
Rigalli A, et al. 1995 Comparative study of the effect of sodium fluoride and sodium monofluorophosphate on glucose homeostasis in the rat. Drug Res 45(3) 289-92
Rigalli, A, Ballina, J C and Puche, R C. 1992 Bone mass increase and glucose tolerance in rats chronically treated with sodium fluoride. Bone and Mineral 16, 101–108
Rigalli, A. 1990 Inhibitory effect of fluoride on the secretion of insulin. Calcif. Tissue Int. 46, 333-338
Schneider, S, Feilen, P J, Schreckenberger, M, Schwanstecher, M, Schwanstecher, C, Buchholz, H G, Thews, O, Oberholzer, K, Korobeynikov, A, Bauman, A, Comagic, S, Piel, M, Schirrmacher, E, Shiue, C Y, Alavi, A A, Bartenstein, P, Rosch, F, Weber, M M, Klein, H H, & Schirrmacher, R 2005 In vitro and in vivo evaluation of novel glibenclamide derivatives as imaging agents for the non-invasive assessment of the pancreatic islet cell mass in animals and humans. Experimental and Clinical Endocrinology and Diabetes, 113 (7) 388-395. *
Seow W K, Thomsett M J. 1994. Dental fluorosis as a complication of hereditary diabetes insipidus: studies of six affected patients. Pediatr Dent 16 128–132
Shahed A R, et al. 1986 Effect of F on rat serum insulin levels in vivo. Journal of Dental Research 65 756.
Stephen, K W 1994 Fluoride toothpastes, rinses, and tablets. Advances in Dental Research 8 185–189

Suketa Y, Asao Y, Kanamoto Y, et al. 1985 Changes in adrenal function as a possible mechanism for elevation of serum glucose by a single large dose of fluoride. Tox Appl Pharm 80 199-205.
Tokar, V I, Zyryanova, V V and Shcherbakov, S V. 1992 Chronic Fluorides Impact on Pancreas Islet Cells in Workers Gigiena i Sanitariia November-December 42-44
Trivedi, N, Mithal, A, Gupta, S K and Godbole, M M. 1993 Reversible impairment of glucose tolerance in patients with endemic fluorosis. Diabetologia 36 826–828
Turner, C H,Garetto, L P,Dunipace, A J, Zhang, W,Wilson, M E,Grynpas, M D,Chachra, D,McClintock, R,Peacock, M and Stookey G K 1997 Fluoride Treatment Increased Serum IGF-1, Bone Turnover, and Bone Mass, but Not Bone Strength, in Rabbits Calcified Tissue International 61(1) 77-83
Vandenberg L N, Colborn T, Hayes T B, Heindel J J, Jacobs D R, Lee D H, Shioda T, Soto A M, vom Saal F S, Welshons W V, Zoeller R T, Myers J P. 2012 Hormones and endocrine-disrupting chemicals: Low dose effects and nonmonotonic dose responses. Endocrine Reviews, 33(3) 378-455.
Varadacharyulu N C, Rao P R. 1997 Gluconeogenesis and glycogenolysis in fluoride-treated rats. Indian Journal of Experimental Biology 35(8) 906-8
Vasant, R A, Kotadiya, D R, Bhole, K L, Narasimhacharya, A V R L. 2010 Therapeutic benefits of glibenclamide in fluoride intoxicated diabetic rats. Fluoride April-June 43(2) 141–149.
Vasant R A, Narasimhacharya A V. 2013a. A multigrain protein enriched diet mitigates fluoride toxicity. Journal of Food Science Technology 50(3) 528-34.
Vasant R A, Narasimhacharya A V. 2013 Limonia fruit as a food supplement to regulate fluoride-induced hyperglycaemia and hyperlipidaemia. Journal of the Science of Food and Agriculture January 93(2) 422-6
Vasant R A, Narasimhacharya A V. 2012 Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations Environmental Health and Preventive Medicine November 17(6) 484-93.
Vogeser, M and Parhofer, K G. 2005 Limited preanalytical requirements for insulin measurement Clinical Biochemistry 38(6) 572-575 *
Wang Z, Yang X, Yang S, Ren G, Ferreri M, Su Y, Chen L and Han B. 2011 Sodium fluoride suppress proliferation and induce apoptosis through decreased insulin-like growth factor-I expression and oxidative stress in primary cultured mouse osteoblasts Archives of Toxicology November 85(11) 1407-17
Weber L P, Chow W L, Abebe W, MacLeod K M. 1996 Enhanced contractile responses of arteries from streptozotocin diabetic rats to sodium fluoride. Br J Pharmacol. May 118(1) 115-22
West R J, Leonard J V. 1980 Familial insulin resistance with pineal hyperplasia: metabolic studies and effect of hypophysectomy. Arch Dis Child 55 619-21
Whitford, G M, Allman D W, and Shahed A R. 1987 Topical fluorides: effects on physiologic and biochemical processes. J Dent Res. 66(5) 1072-8

Wojtaszewski, J F and Richter, E A. 2006 Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscle. Essays in Biochemistry 42 31–34
Wuster, C, Heilmann, P, and Ziegler, R. 1997 Problems of fluoride treatment of patients with osteoporosis in general practice. Experimental and Clinical Endocrinology and Diabetes, 105 (4) A57-A58.
Xie, Yong‐ping, Ge Xiang‐jin, Jiang Yu‐ting, Feng Ming‐ying, Fan Ying‐yi, Wang Fu‐lun, Wei Zeng-fu, Zhao Gui‐lu and Qin Ai‐qiong 2000 Clinical Study of Effect of High Fluoride on the Function of the Pancreas Islet B Cells Chinese Journal of Endemiology 19(2) 84-85
Youlden, D R, Cramb, S M, Baade, P D. 2009 Current status of female breast cancer in Queensland: 1982 to 2006. Viertel Centre for Research in Cancer Control, Cancer Council Queensland. Brisbane, Queensland
Youlden, D R, Cramb, S M, Baade, P D, 2008. Current status of colorectal cancer in Queensland: 1982 to 2005. Viertel Centre for Research in Cancer Control, Cancer Council Queensland: Brisbane. Retrieved 13 Oct 2010
Zhang, P, Zhang, X, Brown, J, Vistisen, D, Sicree, R, Shaw, J and Nichols G. 2010 Global healthcare expenditure on diabetes for 2010 and 2030. Diabetes Research and Clinical Practice, 87(3) 293-301

Water Fluoridation and any other health effects – Cancer

Fluoride causes cancer and one of the most serious mechanisms is very well understood - enhanced deposition of Fluoride doped Hydroxyapatite in the soft tissues that causes malignancy.

I have reviewed the subject here: https://www.researchgate.net/publication/272421380_Fluoride_doped_hydroxyapatite_in_soft_tissues_and_cancer_A_literature_review


Those marked * were deliberately excluded from the 2007 NHMRC review
Aardema, M.J., Gibson, D.P. and R.A. LeBoeuf. 1989. Sodium fluoride-induced chromosome aberrations in different stages of the cell cycle: A proposed mechanism. Mutation Research 223, 191-203.
Aardema, M.J. and T. Tsutsui. 1995. Sodium fluoride-induced chromosome aberrations in different cell cycle stages. Mutation Research 331, 171-172
Albanese, R. 1987. Sodium fluoride and chromosome damage (in vitro human lymphocyte and in vivo micronucleus assays). Mutagenesis 2, 497-9.
Angelloz-Nicoud, P., Harel, L. and Binoux, M. 1996. Recombinant human insulin-like growth factor (IGF) binding protein-3 stimulates prostate carcinoma cell proliferation via an IGF-dependent mechanism. Role of serine proteases. Growth Regulation, 6(3) 130-136 *
Bassin, E.B. 2001. Association between fluoride in drinking water during growth and development and the incidence of osteosarcoma for children and adolescents. D.M.S. Thesis, Harvard School of Dental Medicine, Boston, Massachusetts
Bassin, E.B., Wypij, D., Davis, R.B. and Mittleman, M.A. 2006. Age-specific fluoride exposure in drinking water and osteosarcoma (United States). Cancer Causes and Control 17(4) 421-8.
Begley, S. 2005. Fluoridation, cancer: did researchers ask the right questions? Wall Street Journal (Eastern ed.) p. B1. *
Blakey, K., Feltbower, R.G., Parslow, R.C., James, P.W., Gómez Pozo, B., Stiller, C., Vincent, T.J., Norman, P., McKinney P.A., Murphy M.F., Craft A.W., McNally R.J. 2014. Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great Britain, 1980-2005. International Journal of Epidemiology 43(1) 224-234
Blask, D.E., Sauer, L.A. Dauchy, R.T., Holowachuk, E.W., Ruhoff, M.S. and H.S. Kopff. 1999. Melatonin Inhibition of Cancer Growth in Vivo Involves Suppression of Tumor Fatty Acid Metabolism via Melatonin Receptor-mediated Signal Transduction Events Cancer Research 59, 4693–4701
Blask, D.E., Hill, S.M., Pelletier, D.B. 1988. Oncostatic signaling by the pineal gland and melatonin in the control of breast cancer. In: Gupta D, Attanasio A, Reiter RJ (eds.) The Pineal Gland and Cancer. Brain Research Promotion, London, UK, pp. 195–206.
Bonavita, J.A., Dalinka, M.K. and H.R. Schumacher, Jr. 1980. Hydroxyapatite deposition disease Radiology 134(3) 621-625
Bryson, C. 2004. The Fluoride Deception. New York: Seven Stories Press; paperback edition, 2006.
Burgstahler, A.W., Freeman, R.F., Jacobs, P.N. 2008. Toxic effects of silicofluoridated water in chinchillas, caimans, alligators, and rats held in captivity Fluoride 41(1) 83-88

Burk, D. and Yiamouyiannis, J. 1977. Fluoridation and Cancer: Age Dependence of Cancer Mortality Related to Artificial Fluoridation, 10 Fluoride 123
Burk, D. et al. 1988. A Current Restatement and Continuing Reappraisal Concerning Demographic Variables in American Time-Trend Studies on Water Fluoridation and Human Cancer, 61 Proc. Pa. Acad. of Sci. 138
Byers, M., Kuiper, G.J., Gustafsson, J.A., and Park-sarge, O.K. 1997. Estrogen receptor-α mRNA Expression in rat ovary: down-regulation by gonadotropins. Mol. Endocrinol. 11, 172-182
Campbell-Thompson, M., Lynch, I.J. and Bhardwaj, B. 2001. Cancer Res. 61, 632–640
Cantor, K.P. 1997. Drinking water and cancer. Cancer Causes and Control, 8(3) 292-308. *
Caspary, W.J., Myhr, B., Bowers, L., McGregor, D., Riach, C., Brown, A. 1987. Mutagenic activity of fluorides in mouse lymphoma cells. Mutation Research 187, 165-80.
Castronovo, V., Bellahcene, A. 1998. Evidence that breast cancer associated microcalcifications are mineralized malignant cells. Int J Oncol. 12(2) 305-8
Chang, C.Y., P.H. Phillips, E.B. Hart, and G. Bonstedt. 1934. The effect of feeding raw rock phosphate on the fluorine content of the organs and tissues of dairy cows. J Dairy Sci 17, 695-700 (as cited in Galletti and Joyet 1958).
Chen, T.L., Hou, W.Y., Sun, W.Z., Wu, G.J., Wang, K.C., Peng, W.L., and Lin, C.J. 1997. Metabolic characteristics and enflurane defluorination of cytochrome P450-dependent monooxygenases in human hepatocellular carcinoma, Acta Anaesthesiologica Sinica, 35(1) 7-14. *
Cheng, T.J., Chen, T.M., Chen, C.H., and Lai, Y.K. 1998. Induction of stress response and differential expression of 70 kDa stress proteins by sodium fluoride in HeLa and rat brain tumor 9L cells. Journal of Cellular Biochemistry, 69, (2) 221-231. *
Cohn, P.D. 1992. An Epidemiologic Report on Drinking Water and Fluoridation. New Jersey Department of Health, Trenton, NJ.
Cohn, P.D. 1992. A Brief Report on the Association of Drinking Water Fluoridation and the Incidence of Osteosarcoma among Young Males. New Jersey Department of Health, November 8, 1992.
Cole, J., Muuriel, W.J., Bridges, B.A. 1986. The mutagenicity of sodium fluoride to L5178Y [wild-type and TK+/- (3.7.2c)] mouse lymphoma cells. Mutagenesis 1, 157-167
Comber, H., Deady, S., Montgomery, E., Gavin, A. 2011. Drinking water fluoridation and osteosarcoma incidence on the island of Ireland. Cancer Causes Control. 22(6) 919-24
Connett, P.H., Beck, J. and H.S. Micklem. 2010. The Case against Fluoride. How Hazardous Waste ended up in our drinking water and the Bad Science and Powerful Politics keeps it there. Chelsea Green Publishing Company, White River Junction, Vermont USA

Connett, P.H. 2009. A Critique of the York Review (Fluoridation of Drinking Water: a Systematic Review of its Efficacy and Safety by the NHS Centre for Reviews and Dissemination, the University of York, York, UK)
Cook-Mozaffari, P. 1996. Cancer and fluoridation, Community Dental Health, 13 Suppl 2, 56-62. *
Cooke, M.M., McCarthy, G.M., Sallis, J.D., Morgan, M.P. 2003. Phosphocitrate inhibits calcium hydroxyapatite induced mitogenesis and upregulation of matrix metalloproteinase-1, interleukin-1beta and cyclooxygenase-2 mRNA in human breast cancer cell lines. Breast Cancer Res Treat. 79(2) 253-63
Crespi, C., Seixas, G., Turner, T., Penman, B. 1990. Sodium fluoride is a less efficient human cell mutagen at low concentrations. Environ Mol Mutagen 15, 71-77.
Cullen, M.R., Checkoway, H. and Alexander, B.H. 1996. Investigation of a cluster of pituitary adenomas in workers in the aluminum industry, Occupational and Environmental Medicine, 53(11) 782-786 *
Cvetkovic, D., Movsas, B., Dicker, A. P., Hanlon, A. L., Greenberg, R. E., Chapman, J. D., Hanks, G. E., and Tricoli, J. V. 2001. Increased hypoxia correlates with increased expression of the angiogenesis marker vascular endothelial growth factor in human prostate cancer, Urology, 57(4) 821-825. *
del Río, B., Pedrero, J.M.G., Martínez-Campa, C., Zuazua, P., Lazo, P.S. and S. Ramos. 2004. Melatonin, an Endogenous-specific Inhibitor of Estrogen Receptor via Calmodulin J. Biol. Chem., 279 (37) 38294-38302
Doull, J., Boekelheide, K., Farishian, B.G., Isaacson, R.L., Klotz, J.B., Kumar, J.V., Limeback, H., Poole, C., Puzas, J.E., Reed, N-M.R., Thiessen, K.M., Webster, T.F. National Research Council (NRC) 2006. Committee on Fluoride in Drinking Water Board on Environmental Studies and Toxicology Division on Earth and Life Studies. Fluoride in Drinking Water: A Scientific Review of EPA’s Standards
Easmann, R.P., Steflik, D.E., Pashley, D.H., McKinney, R.V., Whitford, G.M. 1984. Surface changes in rat gastric mucosa induced by sodium fluoride: a scanning electron microscopic study. J Oral Pathol 13, 255–264
Ellison, L.F. 2000. Tea and other beverage consumption and prostate cancer risk: a Canadian retrospective cohort study. Eur J Cancer Prev. 9(2) 125-30
Erciyas, K., Sarikaya, R. 2009. Genotoxic evaluation of sodium fluoride in the Somatic Mutation and Recombination Test (SMART) Food and Chemical Toxicology 47(11), 2860-2
Erickson, J.D., 1978. Mortality in Selected Cities with Fluoridated and Non-Fluoridated Water Supplies. New England Journal of Medicine, 298, 1112-1116,
Eyre, R., Feltbower, R.G., Mubwandarikwa, E., Eden, T.O.B. and R.J.Q. McNally. 2009. Epidemiology of bone tumours in children and young adults. Pediatr. Blood Cancer 53, 941-952
Flora, S.J., Mittal M., Pachauri, V., Dwivedi, N. 2012. A possible mechanism for combined arsenic and fluoride induced cellular and DNA damage in mice. Metallomics 4(1) 78-90

Foley, E.F., Jazaeri, A.A., Shupnik, M.A., Jazaeri, O., and Rice, L.W. 2000. Antitumor effects on advanced breast, ovarian, and colon cancer. Cancer Res. 60, 245–248
Garcia, G.M., McCord, G.C., Kumar, R. 2003. Hydroxyapatite crystal deposition disease. Semin Musculoskelet Radiol. 7(3) 187-93
Gadhia, P.K. and S. Joseph. 1997. Sodium fluoride induced chromosome aberrations and sister chromatid exchange in cultured human lymphocytes. Fluoride 30(3) 153-156.
Gelberg, K.H., Fitzgerald, E.F., Hwang, S. and R. Dubrow. 1995. Fluoride exposure and childhood osteosarcoma: A case-control study. American Journal of Public Health 85 (12) 1678-1683.
Glasser, G. 2011. Death in the Air
Gocke, E., King, M.-T., Eckhardt, K. and D. Wild. 1981. Mutagenicity of cosmetics ingredients licensed by the European Communities. Mutat. Res. 90, 91-109
Grandjean, P. and Olsen, J.H. 2004. Extended follow-up of cancer incidence in fluoride-exposed workers [2], Journal of the National Cancer Institute, 96(10) 802-803 *
Grandjean, P., Olsen, J. H. and Juel, N. 1993. Excess cancer incidence among workers exposed to fluoride Scand. J Work Environ. Health 19(Suppl. 1) 108-109
Guan, Y., Hao, P., Tang, C., Li, P., Li, S., Cheng, X., Ba, Y., Cui, L. 2012. Effect of fluoride on the expression of StAR mRNA and P450scc mRNA in the progesterone synthesis of mouse Leydig tumor cells. Wei Sheng Yan Jiu. 41(1) 105-8.
Gutknecht, J., Walter A. 1981. Hydrofluoric acid and nitric acid transport through lipid bilayer membranes. Biochim Biophys Acta 644, 153-156 cited in Takahashi 2001.
Hayashi, N. and Tsutsui, T. 1993. Cell cycle dependence of cytotoxicity and clastogenicity induced by treatment of synchronized human diploid fibroblasts with sodium fluoride. Mutation Research 290, 293-302
Hayes, C.W. and Conway, W.F. 1990. Calcium Hydroxyapatite Deposition Disease. Radiographics 10, 1031-48
He, L.F. and Chen, J.G. 2006. DNA damage, apoptosis and cell cycle changes induced by fluoride in rat oral mucosal cells and hepatocytes. World Journal of Gastroenterology 12(7) 1144-8
Hein, J.W., Smith, F.A. and F. Brudevold. 1954. Distribution of 1 ppm fluoride as radioactively tagged NaF in soft tissues of adult female albino rats. J Dent Res 33(Oct.) 709-710.
Hein, J.W., Bonner, J.F., Brudevold, F., et al. 1956. Distribution in the soft tissue of the rat of radioactive fluoride administered as sodium fluoride. Nature 178 (4545) 1295–1296.
Herskowitz, I. and Norton, I. 1963. Increased Incidence of Melanotic Tumors in two strains of Drosophila Melanogaster Following Treatment with Sodium Fluoride. Genetics, 48, 307-310

Hirzy, J.W., Carton, R.J., Bonanni, C.D., Montanero, C.M., Nagle, M.F. 2013. Comparison of hydrofluorosilicic acid and pharmaceutical sodium fluoride as fluoridating agents—A cost–benefit analysis. Environmental Science and Policy 38, 282-284
Hirzy, J.W. 1999. Why the EPA's Headquarters Union of Scientists Opposes Fluoridation. Press release from National Treasury Employees Union, May 1, 1999. http://www.fluoridealert.org/hpepa.htm )
Hirzy, J.W. 2000. Statement of Dr. J. William Hirzy, National Treasury Employees Union Chapter 280, before the Subcommittee on Wildlife, Fisheries and Drinking Water, United States Senate, June 29, 2000. Available at http://www.nteu280.org/Issues/Fluoride/629FINAL.htm or http://www.fluoridealert.org/HirzyTestimony.pdf.
Hoover, R.N., Devesa, S.S. Cantor, K.P. Lubin, J.H. and J.F. Fraumeni. 1991. Fluoridation of drinking water and subsequent cancer incidence and mortality. Appendix E in: Review of Fluoride Benefits and Risks. Report of the Ad Hoc Subcommittee on Fluoride of the Committee to Coordinate Environmental Health and Related Programs. U.S. Public Health Service.
Hsu, H., Lacey, D.L., Dunstan, C.R., Solovyev, I., Colombero, A., Timms, E., Tan, H.L., Elliott, G., Kelley, M.J., Sarosi, I., Wang, L., Xia, X.Z., Elliott, R., Chiu, L., Black, T., Scully, S., Capparelli, C., Morony, S., Shimamoto, G., Bass, M.B., Boyle, W.J. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96, 3540–3545.
Huo, L., Liu, K., Pei, J., Yang, Y., Ye, Y., Liu, Y., Sun, J., Han, H., Xu, W. And Y. Gao. 2013. Fluoride Promotes Viability and Differentiation of Osteoblast-Like Saos-2 Cells Via BMP/Smads Signaling Pathway. Biological Trace Element Research. 155(1) 142-149
Jachimczak, D. and Skotarczak, B. 1978. The Effect of Fluorine and Lead Ions on the Chromosomes of Human Leucocytes in Vitro. Genetica Poloncia 19, 353
Jedrychowski, W., Maugeri, U., and Bianchi, I. 1997. Environmental pollution in central and eastern European countries: A basis for cancer epidemiology. Reviews on Environmental Health, 12(1) 1-23 *
Jensen, P.S. 1988. Chondrocalcinosis and other calcifications. Radiol. Clin. North Am. 26 (6) 1315-25
Jones, C.A. et al. 1988. Sodium fluoride promotes morphological transformation of Syrian hamster embryo cells. Carcinogenesis 9, 2279-84
Joseph, S., Gadhia, P.K. 2000. Sister chromatid exchange frequency and chromosome aberrations in residents of fluoride endemic regions of South Gujarat. Fluoride 33, 154-158
Kearney, R. 2015. Melatonin in Health and Disease – Effects of Fluoride. Presented at the Australian Conference on Water Fluoridation, Sydney.
Kesse-Guyot, E., Bertrais, S., Duperray, B., Arnault, N., Bar-Hen, A., Galan, P., Hercberg, S. 2007. Dairy products, calcium and the risk of breast cancer: results of the French SU.VI.MAX prospective study. Ann Nutr Metab. 51(2) 139-45. Epub 2007 May 29

Khalil, A.M. 1995. Chromosome aberrations in cultured rat bone marrow cells treated with inorganic fluorides. Mutation Research 343, 67-74.
Kharb, S., Sandhu, R. and Kundu, Z.S. 2012. Fluoride levels and osteosarcoma. South Asian J Cancer, 1(2) 76-77
Kim, F.M., Hayes C., Williams, P.L., Whitford, G.M., Joshipura, K.J., Hoover, R.N., Douglass C.W. 2011. An assessment of bone fluoride and osteosarcoma Journal of Dental Research 90(10) 1171-6
Kishi, K., and T. Ishida. 1993. Clastogenic activity of sodium fluoride in great ape cells. Mutation Research 301, 183-188.
Knox, E.G. (Chairman). 1985. Fluoridation of water and cancer- A review of the epidemiological evidence (Report of the working party), Her Majesty's Stationery Office, UK pp. 76-83, 100-103. Cited in Takahashi 2001.
Koyama, H., Nakade, O., Takada, Y., Kaku, T. and K.-H. W. Lau. 2002. Melatonin at Pharmacologic Doses Increases Bone Mass by Suppressing Resorption Through Down-Regulation of the RANKL-Mediated Osteoclast Formation and Activation. J Bone Miner Res 17, 1219 –1229
Larsson, S.C., Bergkvist, L. and Wolk, A. Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institute, Sweden. 2009. Coffee and black tea consumption and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort. Cancer Causes and Control, 20(10) 2039-2044
Lasne, C., Lu, Y.-P. and I. Chouroulinkov. 1988. Transforming activities of sodium fluoride in cultured Syrian hamster embryo and BALB/3T3 cells. Cell Biology and Toxicology 4(3) 311-324.
Lazutka, J.R., et al. 1999. Chromosomal aberrations and sister-chromatid exchanges in Lithuanian populations: effects of occupational and environmental exposures. Mutation Research 445, 225-229
Lee, J.R. 1993. Fluoridation and Bone Cancer, Fluoride, Vol.26. No.2 http://www.fluorideresearch.org/262/files/FJ1993_v26_n2_p079-164.pdf
Lenoir, V., de Jonage-Canonico, M.B.Y., Perrin, M.-H., Martin, A., Scholler, R. and B. Kerdelhué. 2005. Preventive and curative effect of melatonin on mammary carcinogenesis induced by dimethylbenz[a]anthracene in the female Sprague–Dawley rat. Breast Cancer Research 7, R470-R476
Lestari, F., Hayes, A.J., Green, A.R. and B. Markovic. 2005. In vitro cytotoxicity of selected chemicals commonly produced during fire combustion using human cell lines. Toxicology in Vitro 19, 653-663
Levy, M., Leclerc, B.S. 2012. Fluoride in drinking water and osteosarcoma incidence rates in the continental United States among children and adolescents. Cancer Epidemiology 36(2) e83-8
Li, S., Smith, K.D., Davis, J.H., Gordon, P.B., Breaker, R.R. and S.A. Strobel. 2013. Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins. Proceedings of the National Academy of Sciences. 110(47) 19018-19023
Liu, H.L., Zeng, Q., Cui, Y.S., Zhang, L., Fu, G., Hou, C.C., Zhao, L., Wang, A. 2014. Fluoride-induced thyroid cell apoptosis. Fluoride 47(2) 161-69

Liu, F., Bloch, N., Bhushan, K.R., De Grand, A.M., Tanaka, E., Solazzo, S., Mertyna, P.M., Goldberg, N., Frangioni, J.V., Lenkinski, R.E. 2008. Humoral bone morphogenetic protein 2 is sufficient for inducing breast cancer microcalcification. Mol. Imaging. 7(4) 175-86
Loder, R. and Sabatino, M. 2015. The Time of the Insult/Triggering Event in Primary Osteosarcoma and Ewing’s Sarcoma of Bone as Determined by Incubation Period Modeling and Age Distribution of Such Malignancies. Epidemiology Research International pp.1-9
Luke, J. 1998. Effects of Fluoride on the Physiology of the Pineal Gland. Fluoride, Vol. 31(3) 129-174
Mahoney, M.C., Nasca P.C., Burnett W.S., Melius J.M. 1991. Bone cancer rates in New York State: time trends and fluoridated drinking water. Am J Pub Health 81, 475–479.
Maity, A., Sall, W., Koch, C. J., Oprysko, P.R., and Evans, S.M. 2001. Low pO2 and beta-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia, Breast Cancer Research and Treatment, 67(1) 51-60 *
Makhoul, I. Harvey, H. Souba, W. and H. Makhoul. 2006. Breast Cancer. Emedicine from WebMD
Manivannan, J., Sinha, S., Ghosh, M., Mukherjee, A. 2012. Evaluation of multi-endpoint assay to detect genotoxicity and oxidative stress in mice exposed to sodium fluoride. Mutation Research 18, 751(1) 59-65
Marcus, W. 1990. Memorandum from Dr. William Marcus, to Alan B. Hais, Acting Director, Criteria and Standards Division ODW, US EPA, DATED MAY 1, 1990, and subsequent memos.
Maurer, J.K., Cheng, M.C., Boysen, B.G., Anderson, R.L. 1990. Two-year carcinogenicity study of sodium fluoride in rats. J Natl Cancer Inst 82, 1118–1126
McCullough, M.L., Bandera E.V., Moore D.F., Kushi L.H. 2008. Vitamin D and calcium intake in relation to risk of endometrial cancer: a systematic review of the literature. Prev. Med. 46(4) 298-302. Epub 2007 Nov 28
Medina, N., Douglass, C. W., Whitford, G. M., Hoover, R. N., and Fears, T. R. 2006. A reproducibility study for a fluoride assay in bone. Cancer Epidemiology Biomarkers and Prevention, 15(5) 1035-1037. *
Meiers, P. 2000. Fluoridation and cancer: Does water fluoridation have negative side effects? A Critique of the New York Review
Mendoza-Schulz, A., Solano-Agama, C., Arreola-Mendoza, L., Reyes-Márquez, B., Barbier, O., Del Razo, L.M., Mendoza-Garrido, M.E. 2009. The effects of fluoride on cell migration, cell proliferation, and cell metabolism in GH4C1 pituitary tumour cells. Toxicology Letters 190(2) 179-86
Meng, Z., Meng, H. and X. Cao. 1995. Sister-chromatid exchanges in lymphocytes of workers at a phosphate fertilizer factory. Mutation Research 334, 243-246.
Meng, Z. and B. Zhang. 1997. Chromosomal aberrations and micronuclei in lymphocytes of workers at a phosphate fertilizer factory. Mutation Research 393, 283-288.

Mihashi, M. and T. Tsutsui. 1996. Clastogenic activity of sodium fluoride to rat vertebral body-derived cells in culture. Mutation Research 368, 7-13.
Mirabello, L., Troisi, R.J. and Savage, S.A. 2009. International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons, Int. J. Cancer 125, 229–234
Mirabello, L., Yu, K., Berndt, S.I., Burdett, L., Wang, Z., Chowdhury, S., Teshome, K., Uzoka, A., Hutchinson, A., Grotmol, T., Douglass, C., Hayes, R.B., Hoover, R.N., Savage, S.A. and for the National Osteosarcoma Etiology Study Group. 2011. A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. BMC Cancer 11, 209
Moreno-Merlo, F., Nicklee, T., and Hedley, D. W. 1999. Association between tissue hypoxia and elevated non-protein sulphydryl concentrations in human cervical carcinoma xenografts. British Journal of Cancer, 81(6) 989-993 *
Morgan, M.P., Cooke M.M., McCarthy G.M. 2005. Microcalcifications associated with breast cancer: an epiphenomenon or biologically significant feature of selected tumors? J Mammary Gland Biol Neoplasia. 10(2) 181-7.
Morgan M.P., Cooke M.M., Christopherson P.A., Westfall P.R., McCarthy G.M. 2001. Calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human breast cancer cell lines. Mol Carcinog. 32(3) 111-7.
Morin, P. et al. 1985. Fluorides, Water Fluoridation, Cancer, and Genetic Diseases, Science and Public Policy 12, 36
Morshed, S.R., Tokunaga, T., Otsuki, S., Takayama, F., Satoh, T., Hashimoto, K., Yasui, T., Okamura, M., Shimada, J., Kashimata, M., and Sakagami, H. 2003. Effect of Antitumor Agents on Cytotoxicity Induction by Sodium Fluoride, Anticancer Research, vol. 23, no. 6 C, pp. 4729-4736. *
Movsas, B., Chapman, J.D., Greenberg, R.E., Hanlon, A.L., Horwitz, E.M., Pinover, W.H., Stobbe, C., and Hanks, G.E. 2000. Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age: An Eppendorf pO2 study, Cancer, vol. 89(9) 2018-2024. *
Moyad, M.A. 2002. Complementary therapies for reducing the risk of osteoporosis in patients receiving luteinizing hormone-releasing hormone treatment/orchiectomy for prostate cancer: A review and assessment of the need for more research, Urology, 59(4 SUPPL. 1) 34-40 *
Mukherjee, R.N., Sobels F.H. 1968. The effects of sodium fluoride and iodoacetamide on mutation induction by x-irradiation in mature spermatozoa of drosophila. Mutat Res 6, 217-25.
Nagakawa, T., Kayahara, M., Ohta, T., Kitagawa, H., Mikami, K., Kurata, T., and Otsuji, S. 2000. Dihydropyrimidine dehydrogenase activity in human pancreatic tumor tissues. Cancer Investigation, 18(6) 516-520 *
National Academy of Sciences. 1977. Drinking Water and Health. National Academy Press, Washington, DC., pp. 388-389.

National Academy of Sciences. 1993. Health Effects of Ingested Fluoride. National Academy Press, Washington, DC. Chapter 6.
Needham, B. 2010. “Killer Smile” Report to Minister for Health and Human Services. Water Fluoridation and Ill Health of at Risk Groups in the Tasmanian Population in 2010.
NTP. National Toxicology Program [NTP]. 1990. Toxicology and Carcinogenesis Studies of Sodium Fluoride in F344/N Rats and B6C3f1 Mice. Technical report Series No. 393. NIH Publ. No 91-2848.
Oguro, A., Cervenka, J. and K. Horii. 1995. Effect of sodium fluoride on chromosomal ploidy and breakage in cultured human diploid cells (IMR-90): An evaluation of continuous and short-time treatment. Pharmacology and Toxicology 76, 292-296
O’Neill, V. J. and Cassidy, J. 2005. Capecitabine in the treatment of colorectal cancer, Future oncology (London), 1(2) 183-190 *
Osmunson B. and A. Adams. 2015. Nomination for the Office of the Report on Carcinogens: Fluoride
Ottaviani G., Jaffe, N. 2009. The epidemiology of osteosarcoma. Cancer Treat Res. 152, 3-13
Ozsvath, D.L. 2009. Fluoride and Environmental Health: a Review. Reviews in Environmental Science and Biotechnology 8(1) 59-79.
Pal, S., Sarkar, C. 2014. Protective effect of resveratrol on fluoride induced alteration in protein and nucleic acid metabolism, DNA damage and biogenic amines in rat brain. Environ Toxicol Pharmacol. 38(2) 684-99.
Palmieri, M.J., Luber, J., Andrade-Vieira, L.F., Davide, L.C. 2014. Cytotoxic and phytotoxic effects of the main chemical components of spent pot-liner: A comparative approach. Mutation Research 763, 30-35
Parsons, W.D., De Villiers, A.J., Bartlett, L.S., Becklake, M.R. 1964. Lung cancer in fluorspar mining community. II. Prevalence of respiratory symptoms and disability. Br. J. Industr. Med. 21, 10
Pashley, D.H., Allison, N.B, Easmann, R.P., McKinney, R.V., Horner, J.A., Whitford, G.M. 1984. The effects of fluoride on the gastric mucosa of the rat. J Oral Pathol 13, 535–545.
Pathi, S.P., Lin, D.D.W., Dorvee, J.R., Estroff, L.A. and C. Fischbach. 2011. Hydroxyapatite nanoparticle-containing scaffolds for the study of breast cancer bone metastasis Biomaterials 32(22), 5112–5122
Pati, P.C., Bhunya S.P. 1987. Genotoxic effect of an environmental pollutant, sodium fluoride, in mammalian in vivo test system. Caryologia 40, 79-87.
Pawar, A.C., Naik, S.J.K., Kumari, S.A. 2014. Cytogenetic analysis of human lymphocytes of fluorosis-affected men from the endemic fluorosis region in Nalgonda district of Andhra Pradesh, India. Fluoride 47(1) 78-84

Podder, S., Chattopadhyay, A., Bhattacharya, S., Ray, M.R., Chakraborty, A. 2011. Fluoride-induced genotoxicity in mouse bone marrow cells: effect of buthionine sulfoximine and N-acetyl-l-cysteine Journal of Applied Toxicology 31(7) 618-25
Podder, S., Chattopadhyay, A., Bhattacharya, S. 2011. Reduction in fluoride-induced genotoxicity in mouse bone marrow cells after substituting high fluoride-containing water with safe drinking water Journal of Applied Toxicology 31(7) 703-5
Podder, S., Chattopadhyay, A., Bhattacharya, S., Ray, M.R. 2008. Differential in vivo genotoxic effects of lower and higher concentrations of fluoride in mouse bone marrow cells. Fluoride 41(4) 301–307
Prystupa, J. 2011. Fluorine—a current literature review. An NRC and ATSDR based review of safety standards for exposure to fluorine and fluorides. Toxicology Mechanisms and Methods 21(2) 103–170
Pujol, P., Rey, J.M., Nirde, P., Roger, P., Gastaldi, M., Laffargue, F., Rochefort, H., and Maudelonde, T. 1998. Differential expression of estrogen receptor- α and –β messenger RNAs as a potential marker of ovarian carcinogenesis. Cancer Res. 58, 5367–5373
Rahman, K.M.W., Shigeyuki, S.T., Watanabe, T., Tanaka, H.M. 2003. Chemopreventive Effects of Melatonin on Diethylnitrosamine and Phenobarbital-Induced Hepatocarcinogenesis in Male F344 Rats Nutrition and Cancer 47(2) 148-155
Ramesh, N., Vuayarahavan, A.S., Desai, B.S., Natarajan, M., Murthy, P.B., Pillai, K.S. 2001. Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. J Environ Pathol Toxicol Oncol 20(3) 237-43
Rao, M.V., Thakur, S.B. 2013. Effects of melatonin and amla antioxidants on fluoride-induced genotoxicity in human peripheral blood lymphocyte cells Fluoride 46(3) 128–134
Rao, M.V., Tiwari, H. 2006. Amelioration by melatonin of chromosomal anomalies induced by arsenic and/or fluoride in human blood lymphocyte cultures. Fluoride 39(4) 255-60
Rao, H.V., Beliles, R.P., Whitford, G.M., Turner, C.H. 1995. A physiologically-based pharmaco-kinetic model for fluoride uptake by bone. Regul Toxicol Pharmacol 22, 30–42
Rivedal, E., et al. 2000. Morphological transformation and effect on gap junction intercellular communication in Syrian hamster embryo cells as screening tests for carcinogens devoid of mutagenic activity. Toxicology In Vitro 14(2), 185-92.
Romundstad, P., Andersen, A., and Haldorsen, T. 2000. Cancer incidence among workers in six Norwegian aluminum plants, Scandinavian Journal of Work, Environment and Health, 26 (6) 461-469 *
Romundstad, P., Haldorsen, T., and Ronneberg, A. 1999. Exposure to PAH and fluoride in aluminum reduction plants in Norway: Historical estimation of exposure using process parameters and industrial hygiene measurements. American Journal of Industrial Medicine, 35(2) 164-174. *

Romundstad, P., Haldorsen, T., and Andersen, A. 2000. Cancer incidence and cause specific mortality among workers in two Norwegian aluminum reduction plants, American Journal of Industrial Medicine, 37(2) 175-183 *
Saidak, Z., Boudot, C., Abdoune, R., Petit, L., Brazier, M., Mentaverri, R., Kamel, S. 2009. Extracellular calcium promotes the migration of breast cancer cells through the activation of the calcium sensing receptor. Exp Cell Res. 315(12) 2072-80.
Sandhu, R., Lal, H., Kundu, Z.S., Kharb, S. 2011. Serum fluoride and sialic acid levels in osteosarcoma Biological Trace Element Research 144(1-3) 1-5
Satoh, R., Kishino, K., Morshed, S. R. M., Takayama, F., Otsuki, S., Suzuki, F., Hashimoto, K., Kikuchi, H., Nishikawa, H., Yasui, T., and Sakagami, H. 2005. Changes in fluoride sensitivity during in vitro senescence of normal human oral cells. Anticancer Research, 25 (3B) 2085-2090. *
Schlesinger, E.R., et al. 1956. Newburgh-Kingston Caries-Fluorine Study XIII. Pediatric Findings after Ten Years. Journal of the American Dental Association, 52 CDC 2012 http://www.cdc.gov/fluoridation/statistics/2012stats.htm
Schmidt, K., Horneber, M., Borrelli, F., and Ernst, E. 2004. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database of Systematic Reviews: Protocols.2004.Issue 4 John.Wiley.and Sons., Ltd. Chichester, UK *
Scott, D. 1986. Cytogenetic effects of sodium fluoride in cultured human fibroblasts. Mutagenesis 1, 69
Scott, D. and S.A. Roberts. 1987. Extrapolation from in vitro tests to human risk: Experience with sodium fluoride clastogenicity. Mutat. Res., 189, 47-58,
Sheth, F.J., et al. 1994. Sister chromatid exchanges: A study in fluorotic individuals of North Gujurat. Fluoride 27, 215-219
Slattery, M.L., West, D.W. 1993. Smoking, alcohol, coffee, tea, caffeine, and theobromine: risk of prostate cancer in Utah (United States). Cancer Causes Control. 4(6) 559-63.
Song, J.S., Park, Y.D., Hyun, J.W. and Kim, J.H. 2005. Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells, Anticancer Research, 25(1 A) 391-395 *
Steiner, G.G. 2002. Cancer incidence rates and environmental factors: An ecological study, Journal of Environmental Pathology, Toxicology and Oncology, 21(3) 205-212
Steiner, D.M. and Steiner, G.G. 2004. Fluoride as an essential element in the prevention of disease. Medical Hypotheses, 62(5) 710-717
Spak, C-J., Sjostedt, S., Eleborg, L., Veress, B., Perbeck, L. and J. Ekstrand. 1989. Tissue response of gastric mucosa after ingestion of fluoride. BMJ 298, 1686-87
Srilatha K., Banji D., Banji O.J.F., Vinod, K.R. and Saidulu, A. 2013. Investigation of the anti-genotoxic effect of ocimum sanctum in fluoride induced genotoxicity. International Research Journal of Pharmacy 4(5) 160-64

Stockbridge, R.B., Kolmakova-Partensky, L., Shane, T., Koide, A., Koide, S., Miller, C. and S. Newstead. 2015. Crystal structures of a double-barrelled fluoride ion channel. Nature, 525, 548-551
Sutton, P.R.N. 1986. Lung Cancer: Is Fluoride in Cigarette Smoke an Etyological Factor? Medical Hypotheses 20, 51
Suzuki, N., Tsutsui, T. 1989. Dependence of lethality and incidence of chromosome aberrations induced by treatment of synchronized human diploid fibroblasts with sodium fluoride on different periods of the cell cycle. [Article in Japanese] Shigaku. 77(2) 436-47.
Suzuki, Y., Li, J., Shimizu, H. 1991. Induction of micronuclei by sodium fluoride. Mutation Research 253(3) 278
Takahashi, K., Akiniwa, K., and Narita, K. 2001. Regression analysis of cancer incidence rates and water fluoride in the U.S.A. based on IACR/IARC (WHO) data (1978-1992). International Agency for Research on Cancer, Journal of Epidemiology / Japan Epidemiological Association, 11(4) 170-179.
Takahashi, N, Udagawa N, Suda T. 1999. A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/ RANKL, regulates osteoclast differentiation and function. Biochem Biophys Res Commun 256, 449–455
Taylor, A. and N.C. Taylor. 1965. Effect of Fluoride on Tumor Growth, Proceedings of the Society of Experimental Biology and Medicine, 65, 252-255
Tazhibaev Sh.S., et al. 1977. [Modifying effect of nutrition on the mutagenic activity of phosphorus and fluorine compounds]. Vopr Pitan. Jul-Aug (4) 63-6.
Thakur, S.B., Rao, M.V. 2014. In vitro fluoride induced genotoxic effect on human blood lymphocyte cells and its amelioration by emblica officinalis extract Molecular Cytogenetics 7 (Suppl 1) 48
Thiessen, K.M., Limeback, H., Beck, J., Micklem, H.S., Litras, S., Spittle, B., Atkin, G.M. 2014. Scientific and Critical Analysis of the 2014 New Zealand Fluoridation Report. International Critique of the Royal Society of New Zealand/Office of the Prime Minister’s Chief Science Advisor’s Fluoridation Report: Health effects of water fluoridation: A review of the scientific evidence. Fluoride Free New Zealand. Accessed from www.fluoridefree.org.nz
Thiessen, K.M. 2011. Comments in response to Evidence on the Carcinogenicity of Fluoride and Its Salts. July 2011 Reproductive and Cancer Hazard Assessment Branch, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency
Tohyama, E. 1996. Relationship between fluoride concentration in drinking water and mortality rate from uterine cancer in Okinawa prefecture, Japan. Journal of epidemiology / Japan Epidemiological Association 6(4) 184-191. *
Tohyama, E. 1995. Drinking water quality and its relationship with the mortality rate in Okinawa prefecture. Japanese J of Health and Human Ecology, 61 (2) 69-82
Tokar, U.T., Savchenko, O.N. 1977. Effect of inorganic fluoride compounds on the functional state of the pituitary-testis system, Probl Endoklinol (Mosk) 23, 104-107, cited in Takahashi 2001

Tokunaga, T., Morshed, S.R.M., Otsuki, S., Takayama, F., Satoh, T., Hashimoto, K., Yasui, T., Ogawa, S., Kanegae, H., Yokote, Y., Akahane, K., Kashimata, M., Satoh, K., and Sakagami, H. 2003. Effect of Antioxidants, Oxidants, Metals and Saliva on Cytotoxicity Induction by Sodium Fluoride, Anticancer Research, 23(5A) 3719-3726 *
Torell, J.A., Knight, J.P., Marcus, P.B. 1984. Intraluminal calcium hydroxyapatite crystals in breast carcinoma: an ultrastructural study. Ultrastruct Pathol. 6(1)9-14
Tsutsui, T., Suzuki, N., Ohmori, M., and Maizumi, H. 1984. Cytotoxicity, chromosome aberrations and unscheduled DNA synthesis in cultured human diploid fibroblasts induced by sodium fluoride. Mutat. Res. 139, 193-198
Tsutsui, T. et al. 1991. Cytotoxicity and Chromosome Aberrations in Normal Human Oral Keratinocytes Induced by Chemical Carcinogens: Comparison of Inter-Individual Variations, Toxicology in Vitro 5, 353
Turner, C.H., Garetto, L.P., Dunipace, A.J., Zhang, W., Wilson, M.E., Grynpas, M.D., Chachra, D., McClintock, R., Peacock, M., and Stookey, G.K. 1997. Fluoride treatment increased serum IGF-1, bone turnover, and bone mass, but not bone strength, in rabbits. Calcif. Tissue Int. 61, 77-83
US Public Health Service. 1991. Review of fluoride: benefits and risks, Report of the Ad Hoc Subcommittee on Fluoride. Public Health Service, Atlanta, cited in Takahashi 2001.
Varner, J.A., Jensen, K.F., Horvath, W., Isaacson, R.L. 1998. Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Res. 784, 284-298 cited in Takahashi 2001.
Vazquez-Alvarado P., Melendez-Ocampo A., Ortiz-Espinosa R.M., Munoz-Juarez S., Hernandez-Ceruelos A. 2012. Genotoxic damage in oral epithelial cells induced by fluoride in drinking-water on students of Tula de Allende, Hidalgo, Mexico Journal of Toxicology and Environmental Health Sciences 4(8) 123-129
Venkateswarlu, P., Zero, D.T. 1994. Report for Working Group I: strategies for improving the assessment of fluoride accumulation in body fluids and tissues. Adv Dent Res 8, 113–115.
Wang, A.-G., T. Xia, Q.-L. Chu, M. Zhang, F. Liu, X.-M. Chen, and K.-D. Yang. 2004. Effects of fluoride on lipid peroxidation, DNA damage and apoptosis in human embryo hepatocytes. Biomedical and Environmental Sciences 17, 217-222.
Waugh, D. 2014. Health impacts of water fluoridation. Presentation to Nutritional Therapists of Ireland.
Wergedal, J.E., Lau, K-H.W., Baylink, D.J. 1988. Fluoride and bovine bone extract influence cell proliferation and phosphatase activities in human bone cell cultures. Clin Orthop Relat Res 233, 274–82
Whitford, G.M. 1994. Intake and metabolism of fluoride. Adv Dent Res 8, 5–14.

Whitford, G.M., Bawden, J.W., Bowen, W.H., Brown, L.J., Ciardi, J.E., Clarkson, T.W., Imrey, P.B., Kleerekoper, M., Marthaler, T.M., McGuire, S., Ophaug, R.H., Robinson, C., Schultz, J.S., Stookey, G.K., Tochman, M.S., Whitford, G.M., Biles, E.D., Birdsong-Whitford, N.L. 1991. A comparative study of fluoride pharmacokinetics in five species. J Dent Res 70, 948–951.
Whitford, G.M. 1996. The metabolism and Toxicity of Fluoride. 2nd Rev. Ed. Monographs in Oral Science Vol. 16. New York: Karger.
Whitford, G.M. 1999. Fluoride metabolism and excretion in children. J Pub Health Dent 59, 224–228.
Whitford, G.M., Buzalaf, M.A., Bijella M.F., Waller, J.L. 2005. Plaque fluoride concentrations in a community without water fluoridation: effects of calcium and use of a fluoride or placebo dentifrice. Caries Res 39, 100–107.
Whitford, G.M., Sampaio, F.C., Arneberg, P., von der Fehr, F.R. 1999. Fingernail fluoride: a method for monitoring fluoride exposure. Caries Res 33, 462–467.
Whitford, G.M., Thomas, J.E., Adair S.M. 1999. Fluoride in whole saliva, parotid ductal saliva and plasma in children. Arch Oral Biol 44, 785–788.
Wikipedia 2015. Laki. https://en.wikipedia.org/wiki/Laki accessed October 2105.
Wilson, George H. III et al. 2014. An Approach to Breast Cancer Diagnosis via PET Imaging of Microcalcifications using 18F-NaF. The Journal of Nuclear Medicine 7, 1138-1143
Wu, D.Q., and Y. Wu. 1995. Micronucleus and sister chromatid exchange frequency in endemic fluorosis. Fluoride 28(3) 125-127.
Xie, M., Yang, D., Liu, L., Xue, B., and Yan, B. 2002. Human and rodent carboxylesterases: Immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, and tumor-related expression. Drug Metabolism and Disposition, 30(5) 541-547 *
Yang, C.Y., Cheng, M.F., Tsai, S.S., and Hung, C.F. 2000. Fluoride in drinking water and cancer mortality in Taiwan. Environmental Research, 82(3), 189-193
Yiamouyiannis, J.A. and Burk, D. 1977. Fluoridation and Cancer: Age Dependence of Cancer Mortality Related to Artificial Fluoridation, Fluoride, 10 (3) 102-123
Yiamouyiannis, J. 1993. Fluoridation and Cancer: The Biology and Epidemiology of Bone and Oral Cancer Related to Fluoridation, Fluoride 26, 83
Yu, F., Jin, Z., Jiang, H., Xiang, C., Tang, J., Li, T. and J. He. 2014. Tea consumption and the risk of five major cancers: a dose–response meta-analysis of prospective studies. BMC Cancer 14, 197
Zhang R., Niu Y., Du H., Cao X., Shi D., Hao Q., Zhou Y. 2009. A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell Toxicology in Vitro 23(1) 158-65

Zhang M., et al. 2008. Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-kappaB in primary cultured rat hippocampal neurons. Toxicology Letters 179(1) 1-5.
Zhang Y., Sun X., Sun G., Liu S., Wang L. 2006. DNA damage induced by fluoride in rat osteoblasts. Fluoride 30(3), 191-94
Zhang X., Albanes D., Beeson, W.L., van den Brandt P.A., Buring, J.E., Flood, A., Freudenheim, J.L., Giovannucci, E.L., Goldbohm, R.A., Jaceldo-Siegl, K., Jacobs, E.J., Krogh, V., Larsson, S.C., Marshall, J.R., McCullough, M.L., Miller, A.B., Robien, K., Rohan, T.E., Schatzkin, A., Sieri, S., Spiegelman, D., Virtamo, J., Wolk, A., Willett, W.C., Zhang, S.M., Smith-Warner, S.A. 2010. Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. J Natl Cancer Inst 102(11), 771–783
Ziegelbecker, R. 1987. Zur Frage eines Zusammenhanges zwischen Trinkwasserfluordierung, Krebs, und Leberzirrhose, 218 GWF Wasser/Abwasser 111

 See also this recent contribution and all references therein:




You must be condemned over your failure to adequately review the known Neurotoxin Fluoride,

Other experts will deliver excellent reviews on this topic


Supertoxic elements delivered deliberately to the population via Fluoridation chemicals.

It is scandalous that you fail to deal with major hazards present in the industrial Fluoride waste used to poison Australian water.

The elements which are not safe at any level are the Genotoxic Class I carcinogens:






Thorium and its decay products

Uranium and its decay products

The target for these elements is ZERO and yet you condone the deliberate addition of them to water and food prepared with that water contaminated by deliberate addition of industrial Fluoride waste!

Q2. A) Is it clear how NHMRC reviewed the health and dental effects of water fluoridation? : 
Q2. B) Please provide details regarding you response to Question 2A: 

The NHMRC deliberately excluded consideration of essential science by making ridiculous exclusion criteria.

Q3. A) Is the Fluoride Reference Group’s interpretation of the evidence clearly described in the draft Information Paper?: 
Q3. B) Please provide details regarding your response to Question 3A: 

The FRG's interpretation of the tiny amount of selected evidence is biased due to the composition of the panel.

Q5. Is there additional evidence on any other health effects of water fluoridation that should be considered in the draft Information Paper?: 

See all the references supplied in answer to Question 1. plus these highly relevant papers. 2016 letter to the National Governors Association from consumer advocate Erin Brockovich, water specialist Robert Bowcock, and “elite” whistleblower attorney Michael D. Kohn (lobbying & advocacy) http://fluoridealert.org/wp-content/uploads/brockovich-2016.pdf 2016 letter to the American Thyroid Association from Richard Shames, MD, et al. (endocrine disruption & cancer) http://www.ehcd.com/wp-content/uploads/2016/02/2016_02_11_ATALtrCWF.pdf 2015 letter to Institute of Medicine from Erin Brockovich, American Academy of Environmental Medicine, “super lawyer” David P. Matthews, et. al. (contraindications & safety): https://www.aaemonline.org/pdf/LetterIOM_2015.04.27.pdf 2015 IAOMT position paper opposing fluoridation (toxicity & carcinogenicity): https://iaomt.org/iaomt-position-fluoridation/ 2014 Canadian legal memo and scientific affidavit of 2006 NRC panelist, Dr. Kathleen Thiessen (disproportionate harm & susceptible populations): http://momsagainstfluoridation.org/sites/default/files/Fluoridation-Lega... 2016 Fluoride, Chloramine & Lead Resource Sheet (bad for people, pipes, and planet): http://momsagainstfluoridation.org/sites/default/files/pdf-documents/Flu... 2016 Comment on Oral Health Coalition thesis (intimidation & deception): https://drive.google.com/open?id=0BxPjobYjirCIMDdEaF90WE44VzQ Video showing the [NHMRC has removed third party information] acknowledgement, behind closed doors, of the harms of Fluoridation https://www.youtube.com/watch?v=SjSp3Bzgu4I&feature=youtu.be

Q6. Is there any other supporting material relevant to making decisions on water fluoridation in the Australian context that should be considered in the draft Information Paper?: 

Work by real scientists using high technology has debunked the theory that Fluoride has any value in mineralization or remineralization of tooth enamel. See for example the excellent work of Professor of Dentistry Mitsuo Kakei and his coworkers Aspects Regarding Fluoride Treatment for Reinforcement and Remineralization of Apatite Crystals Journal of Hard Tissue Biology 21[3] (2012) p257-266 These workers found that "fluorapatite crystals were not generated by daily intake of F ions in developing rat tooth enamel. A differential gas pressure method demonstrated that the harmfulness of F exposure during the nucleation process of calcified hard tissues was much greater than that of Cd exposure. These results demonstrate that F treatments have no effect on improving crystal quality or remineralization and are inconsistent with the purpose of public health." Similarly, real scientists using advanced technology have shown that exposure of tooth enamel to Fluoride produces, at most, only 6nm depth of fluoride attachment and this is likely an over-estimate because surface roughness and increasing crater diameter during ion ablation increases the apparent depth of penetration. See https://www.researchgate.net/publication/49621915_Elemental_Depth_Profil... Failure to consider excellent reviews of Fluoride Toxicology is negligent. See for example the excellent review by Barbier et al https://www.researchgate.net/publication/45281342_Molecular_mechanisms_o...

Page reviewed: 4 July, 2017